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REC-1245 for Cancer (No information Trial)

West Valley City, UT
Phase 1 & 2
Recruiting
Research Sponsored by Recursion Pharmaceuticals Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18 years or older
Histologically-confirmed unresectable, locally advanced, or metastatic select solid tumors or select relapsed/refractory lymphoma
Must not have
Received treatment with another RBM39 degrader
Clinically significant gastrointestinal (GI) or GI malabsorption
Timeline
Screening 3 weeks
Treatment Varies
Follow Up initiation from study drug until disease progression [up to approximately 24 months]
Awards & highlights
No Placebo-Only Group

Summary

This trial will check if a new drug called REC-1245 is safe and effective when taken by mouth once a day by people with advanced solid tumors that cannot be removed by surgery.

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Who is the study for?
This trial is for individuals with cancers that can't be removed by surgery, are locally advanced, or have spread to other parts of the body. It's open to those with primary cancer, oral and head & neck cancers, or lymphoma.Check my eligibility
What is being tested?
The study is testing REC-1245, a new medication given orally once daily. The goal is to assess its safety and how well it works in treating various advanced cancers.See study design
What are the potential side effects?
Specific side effects of REC-1245 aren't listed here but generally may include nausea, fatigue, allergic reactions or other symptoms depending on individual patient response.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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My cancer is advanced and cannot be removed by surgery.
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I am fully active and can carry on all my pre-disease activities without restriction.
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My cancer can be measured by scans according to specific criteria.
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My cancer has worsened or returned after treatment, or I can't tolerate standard cancer treatments.
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Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have been treated with an RBM39 degrader before.
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I have serious stomach or nutrient absorption problems.
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Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~initiation from study drug until disease progression [up to approximately 24 months]
This trial's timeline: 3 weeks for screening, Varies for treatment, and initiation from study drug until disease progression [up to approximately 24 months] for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Phase 1-Part 1A [Dose Finding]- Assessment of Dose limiting toxicities [DLTs]
Phase 1/2 -Treatment emergent adverse events
Phase 2- Objective Response Rate [ORR]
Secondary study objectives
Phase 1- Objective Response Rate [ORR]
Phase 1/2 - maximum plasma concentration (Cmax)
Phase 1/2 - plasma concentration before the next dose (Ctrough) and Area under plasma concentration-time c
+7 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Group I: Phase 1b Dose #2Experimental Treatment1 Intervention
Dose #2 TBD
Group II: Phase 1b Dose #1Experimental Treatment1 Intervention
Dose Confirmation
Group III: Phase 1aExperimental Treatment1 Intervention
Dose Escalation

Find a Location

Closest Location:Cleveland Clinic· Cleveland, OH· 127 miles

Who is running the clinical trial?

Recursion Pharmaceuticals Inc.Lead Sponsor
5 Previous Clinical Trials
367 Total Patients Enrolled
~57 spots leftby Oct 2028