Aspirin for Preeclampsia

(ASAPP Trial)

Recruiting in Palo Alto (17 mi)

Overseen by Megan C Oakes, MD MSCI

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Recruiting

Sponsor: MemorialCare Health System

No Placebo Group

Prior Safety Data

Approved in 4 Jurisdictions

Trial Summary

What is the purpose of this trial?

The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.

Research Team

Megan C Oakes, MD MSCI

Principal Investigator

Miller Children's and Women's Hospital, Long Beach/ MemorialCare Medical Center

Eligibility Criteria

This trial is for women who have just given birth and were diagnosed with severe preeclampsia during delivery. They must be receiving care from the Long Beach Memorial Ob/Gyn or Maternal-Fetal Medicine clinic.

Inclusion Criteria

I was diagnosed with severe preeclampsia during my delivery.

You receive prenatal and postnatal care from the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic.

Treatment Details

Interventions

• Aspirin (Antiplatelet Agent)

Trial Overview The study is testing if low-dose aspirin can help women recover faster from severe preeclampsia after childbirth by lowering a protein linked to high blood pressure in pregnancy.

Participant Groups

Group I: Standard blood pressure control plus aspirin 81 mg Experimental Treatment 1 Intervention

Standardized postpartum blood pressure control Aspirin 81 mg by mouth x 1 week post-delivery

Group II: Standard blood pressure control Active Control 1 Intervention

Standardized postpartum blood pressure control

Aspirin is already approved in Canada, China for the following indications:

Approved in Canada as Aspirin for:

• Pain relief
• Fever reduction
• Inflammation
• Cardiovascular disease prevention
• Preeclampsia prevention

Approved in China as Aspirin for:

• Pain relief
• Fever reduction
• Inflammation
• Cardiovascular disease prevention

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Miller Children's and Women's Hospital, Long Beach/MemorialCare Long Beach Long Beach, CA

Who Is Running the Clinical Trial?

MemorialCare Health System

Lead Sponsor

Trials

21

Patients Recruited

2,600+

University of California, Irvine

Collaborator

Trials

580

Patients Recruited

4,943,000+