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Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

N/A
Waitlist Available
Led By Caroline O Cobb, PhD
Research Sponsored by Virginia Commonwealth University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up recorded throughout each 3 hour and 05 minute/ 3 hour and 40 minute study session using automated software every 10 seconds.
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to understand how using e-cigarettes affects behaviors related to addiction by studying the rate at which nicotine is delivered. It focuses on individuals who use e-cigarettes to see if faster or higher nicotine delivery increases the likelihood of addiction.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~recorded throughout each 3 hour and 05 minute/ 3 hour and 40 minute study session using automated software every 10 seconds.
This trial's timeline: 3 weeks for screening, Varies for treatment, and recorded throughout each 3 hour and 05 minute/ 3 hour and 40 minute study session using automated software every 10 seconds. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Breakpoint of Drug Purchase Task (DPT)
Effort for Product Puffs with Cross Product Progressive Ratio Task (CP-PRT)
Effort for Product Puffs with Progressive Ratio Task (PRT)
Other study objectives
Change in Diastolic Blood Pressure
Change in Heart Rate
Change in Systolic Blood Pressure
+5 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

5Treatment groups
Experimental Treatment
Active Control
Group I: ECIG 30 Watts, 8 mg/ml nicotineExperimental Treatment1 Intervention
Group II: ECIG 30 Watts, 30 mg/ml nicotineExperimental Treatment1 Intervention
Group III: ECIG 30 Watts, 15 mg/ml nicotineExperimental Treatment1 Intervention
Group IV: ECIG 30 Watts, 0 mg/ml nicotineExperimental Treatment1 Intervention
Group V: Own Brand CigaretteActive Control1 Intervention

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)NIH
2,594 Previous Clinical Trials
3,328,704 Total Patients Enrolled
10 Trials studying Vaping
5,072 Patients Enrolled for Vaping
Virginia Commonwealth UniversityLead Sponsor
717 Previous Clinical Trials
22,895,666 Total Patients Enrolled
Caroline O Cobb, PhDPrincipal InvestigatorVirginia Commonwealth University
2 Previous Clinical Trials
250 Total Patients Enrolled
Andrew Barnes, PhDPrincipal InvestigatorVirginia Commonwealth University
2 Previous Clinical Trials
88 Total Patients Enrolled

Media Library

Vaping Clinical Trial 2023: Tobacco product administration and assessment Highlights & Side Effects. Trial Name: NCT04332926 — N/A
Tobacco product administration and assessment (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04332926 — N/A
~7 spots leftby Dec 2025
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