Behavioral Intervention
ENTRUST Program for Substance Use Disorder and HIV/AIDS
"This trial aims to study the effectiveness of a program called ENTRUST in helping transgender women in Florida who are at high risk for substance use disorders and HIV. ENTRUST provides financial education and counseling
Behavioral Intervention
Adapted Intervention for Smoking Cessation
This trial aims to understand how stress related to gender identity affects smoking habits in transgender and gender diverse individuals. The study will modify an existing smoking cessation program to better suit the needs of this population and test
Behavioural Intervention
Peer Support for Gender Confirmation Surgery
This trial focuses on improving health outcomes for transgender and nonbinary individuals seeking gender-affirming surgery. The study compares the effectiveness of a virtual peer support group versus usual care in preparing patients for vagin
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Trials for HIV Patients
Behavioural Intervention
Mobile App Intervention for Risky Alcohol Use
This trial will use mobile apps to deliver messages to reduce risky drinking & HIV risk in sexual minority males & transgender persons. They'll also take surveys & breathalyzer readings to measure outcomes.
Antiretroviral Agent
APRETUDE for HIV Prevention
This trial studies how well a drug called Cabotegravir works to prevent HIV infection, and how easy it is to give to people in a clinical setting. It looks at two types of participants: those receiving the drug, and those administering it.
Antiretroviral
PrEP for HIV Prevention in Transgender Individuals
This trial will study PrEP levels in trans/non-binary folks taking gender-affirming hormones. They'll get personalized text reminders and take F/TAF for 48 weeks. 60 people will be enrolled.
Behavioural Intervention
Financial Stability and Counseling for Transgender Women
This trial aims to test the idea that helping transgender women with financial stability and counseling will make it more likely for them to use substance abuse and HIV prevention services. Additionally, it will see if transgender women
Trials for Trans Patients
Behavioral Intervention
Online Intervention for Transgender Young Adults' Alcohol Use
This trial aims to learn more about an online resource called Whole Selves, designed to help transgender and/or nonbinary young adults reflect on their experiences and goals related to alcohol use and romantic relationships. The
Decision Aid for Gender Dysphoria
This trial aims to test a new online tool that provides information to help individuals considering Gender Affirming Surgery make informed decisions. Participants will either receive standard care or use the web-based decision aid and provide
Behavioral Intervention
Empowered Relief for Chronic Pain
This trial aims to see if a 2-hour group therapy session can help transgender or gender-diverse patients with chronic pain feel less distressed before their gender-affirming surgery compared to those who do
Behavioral Intervention
Digital Platform for Transgender Mental Health
This trial aims to test an educational app for transgender and gender-diverse young adults and their caregivers to see if it improves mental health outcomes. Participants will be split into two groups: one with immediate
Hormone Therapy
Estradiol + Biktarvy for Trans Women Living with HIV
This trial investigates whether common hormone treatments for transgender women interfere with a specific HIV medication. It focuses on transgender women with HIV who are concerned about drug interactions. The study will measure drug and hormone levels in the blood to see if they affect each other.
Antiretroviral Agent
PrEP + Hormone Therapy for HIV Prevention in Transgender Women
This trial is to study the best way to dose Truvada®, an oral medication that can be taken as Pre-Exposure Prophylaxis (PrEP) to prevent HIV infection, in transgender women who are also taking feminizing hormones.
Trials With No Placebo
Behavioral Intervention
GAP Training for Mental Health Provider Education
This trial aims to improve mental health care for gender minority youth by testing an intervention to increase providers' use of gender-affirming practices. A future RCT will assess feasibility and acceptability.
Behavioural Intervention
Mobile App Intervention for Risky Alcohol Use
This trial will use mobile apps to deliver messages to reduce risky drinking & HIV risk in sexual minority males & transgender persons. They'll also take surveys & breathalyzer readings to measure outcomes.
Antiretroviral Agent
APRETUDE for HIV Prevention
This trial studies how well a drug called Cabotegravir works to prevent HIV infection, and how easy it is to give to people in a clinical setting. It looks at two types of participants: those receiving the drug, and those administering it.
Behavioral Intervention
MyPEEPS Mobile for HIV Prevention
This trial is testing a new way to prevent HIV infection in young transgender men, who are at high risk for the disease. If successful, this could be a life-saving intervention for this vulnerable population.
Behavioral Intervention
Interpersonal Psychotherapy for Alcoholism
This trial will study whether an adapted version of interpersonal psychotherapy (IPT) is an effective treatment for alcohol use disorder (AUD) in gender minority (GM) individuals. GM individuals experience disproportionately high rates of hazardous drinking and AUD, and there are no evidence-based alcohol interventions for this population. The study will use mixed-methods formative research with an established multi-site longitudinal GM cohort to develop and assess the feasibility of the adapted IPT intervention.
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Frequently Asked Questions
Introduction to transgender
What are the top hospitals conducting transgender research?
In recent years, there has been a growing recognition of the unique healthcare needs of transgender individuals. Hospital institutions across the United States have taken strides to address these needs through clinical trials focusing on transgender health. One such institution is the University of Wisconsin in Madison, which currently has three ongoing trials specifically dedicated to transgender patients. Although relatively new to this field, with only two recorded trials thus far and their first trial documented in 2024, their commitment to advancing transgender healthcare is commendable.
Moving over to the West Coast, San Francisco’s Bridge HIV CRS plays a pioneering role in addressing the medical concerns faced by transgender individuals. With two active clinical trials underway and no previous recorded studies exclusively focused on transgender health, this hospital demonstrates a forward-thinking approach that aims to bridge gaps in knowledge regarding effective interventions for this community.
Similarly, New york's Harlem Prevention Center CRS and Philadelphia's Penn Prevention CRS are also actively engaged in two ongoing transgender clinical trials each but do not have any prior history of conducting specific research for gender-affirming healthcare before now.
Meanwhile, Houston AIDS Research Team CRS stands as another key player striving towards improving trans-inclusive care by running two current clinical studies centered around transgender participants but like some others mentioned hasn't conducted any past investigations related solely toward this population till date.
These hospitals signify significant progress within the medical community when it comes to acknowledging and accommodating diverse identities within healthcare research. By devoting resources and expertise toward understanding and addressing the unique challenges faced by transgender individuals, these institutions are driving advancements that will ultimately lead to a more inclusive and supportive future for all members of society.
Which are the best cities for transgender clinical trials?
When it comes to transgender clinical trials, several cities stand out as hubs for research and development. New york, with its 16 active trials, offers studies like Group 1: BIC-treated and Arm A. Chicago follows closely behind with 7 ongoing trials focusing on interventions such as Focus Groups and F/TAF. Los Angeles also plays a significant role, hosting 6 active trials examining treatments like Prep N' Shine: Strength Based Case Management (Stage 1) and Surgery-specific general anesthetic + ultrasound guided peripheral nerve block #2. Lastly, San Francisco and Houston each have 5 active trials contributing to the advancement of transgender healthcare. These cities provide valuable opportunities for individuals in the transgender community to participate in cutting-edge clinical research that can lead to improved care options tailored specifically to their needs.
Which are the top treatments for transgender being explored in clinical trials?
In the realm of transgender healthcare, clinical trials are paving the way for innovative treatments. The top contenders currently being explored in these trials include:
- Hormone Replacement Therapy (HRT): Studying different hormone regimens and delivery methods to optimize physical transition
- Gender-Affirming Surgeries: Investigating techniques and outcomes of various surgical procedures like chest reconstruction or genital reconstruction
- Voice Therapy: Exploring interventions to help individuals modify their vocal pitch and resonance to align with their gender identity These ongoing studies aim to enhance the quality of care available for transgender individuals, providing them with more options and personalized treatment approaches.
What are the most recent clinical trials for transgender?
Exciting progress is being made in the field of transgender healthcare through recent clinical trials. One such trial investigates the effectiveness of Clascoterone, a potential treatment for individuals undergoing gender transition. This trial spans both Phase 1 and Phase 2, offering hope for enhanced hormone therapy options. Additionally, an ongoing Phase 4 study called Enhanced Implementation (EI) focuses on improving the implementation of transgender healthcare practices to ensure optimal outcomes and accessibility. Another significant trial explores surgery-specific general anesthesia combined with ultrasound-guided peripheral nerve block #2 as a means to improve surgical experiences for transgender patients. Furthermore, a Phase 2 study examines the efficacy of twice-daily sublingual estradiol plus spironolactone in hormone therapy regimens tailored specifically towards transgender individuals. These groundbreaking trials mark important steps forward in enhancing care and well-being within the transgender community.
What transgender clinical trials were recently completed?
Recently completed clinical trials have focused on advancing transgender healthcare and addressing the unique needs of this community. Notable among them is a trial conducted by University College London that investigated hormone therapy for transgender individuals, with results expected to shape future treatment approaches. Another significant study, led by The Fenway Institute in Boston, examined the impact of gender-affirming surgeries on mental health outcomes in transgender people. These groundbreaking trials contribute valuable insights into improving the overall well-being and quality of care for transgender individuals.