Vitamin Supplement
Vitamin D for Sickle Cell Anemia
This trial tests if vitamin D3 can lower lung issues in kids with sickle cell disease. It compares different dosing schedules to see which works better. The goal is to find a simple, low-cost way to help these children stay healthier. Vitamin D has been studied for its potential to reduce respiratory complications in children with sickle cell disease due to its ability to fight infections and support the immune system.
CAR T-cell Therapy
VST Therapy for Post-Transplant Viral Infections
This trial is designed to evaluate the safety of rapidly generated multivirus-specific T-cell products with antiviral activity against CMV, EBV, adenovirus, HHV6, BK virus, JC virus, and human parainfluenza-3 (HPIV3), derived from eligible HSCT donors.
Pathogen Reduction System
INTERCEPT Blood System for Blood Transfusion Safety
This trial is designed to study the safety and efficacy of the INTERCEPT Blood System for pathogen reduction of red blood cells in comparison to conventional methods. If successful, the system may be made available in areas where transfusion-transmissible infections are common.
Popular Filters
Trials for Respiratory Syncytial Virus Patients
Monoclonal Antibodies
Clesrovimab for Respiratory Syncytial Virus
This trial is testing two medications, clesrovimab and palivizumab, to see if they are safe and well-tolerated by people who might need them. The study will look at any side effects experienced by participants. Palivizumab is a treatment approved in 1998 for high-risk children against respiratory infections and is now approved in over 45 countries.
Virus Therapy
RSV Vaccine for Respiratory Syncytial Virus
This trial tests a new RSV vaccine given as nose drops to help protect against lung infections caused by the RSV virus. It involves healthy children and infants, including those who have and have not had an RSV infection before. The vaccine works by teaching the body to recognize and fight the virus.
Virus Therapy
RSV ΔNS2/Δ1313/I1314L +2 More for Respiratory Syncytial Virus
The purpose of this study is to evaluate the infectivity, safety, and immunogenicity of the recombinant live-attenuated respiratory syncytial virus (RSV) vaccines RSV ΔNS2/Δ1313/I1314L or RSV 276 or placebo when delivered as nose drops to RSV-seronegative infants and children 6 to 24 months of age. This study is a companion study to IMPAACT 2018.
Trials for Respiratory Syncytial Virus Infection Patients
Virus Therapy
RSV Vaccine for Respiratory Syncytial Virus
This trial tests a new RSV vaccine given as nose drops to help protect against lung infections caused by the RSV virus. It involves healthy children and infants, including those who have and have not had an RSV infection before. The vaccine works by teaching the body to recognize and fight the virus.
Virus Therapy
RSV Vaccine for Older Adults
This trial is testing a new RSV vaccine by GSK in adults aged 60 and above. The vaccine aims to boost the immune system's ability to fight RSV. The study will also look at how safe the vaccine is and how long its effects last.
Phase 3 Trials
Monoclonal Antibodies
Clesrovimab for Respiratory Syncytial Virus
This trial is testing two medications, clesrovimab and palivizumab, to see if they are safe and well-tolerated by people who might need them. The study will look at any side effects experienced by participants. Palivizumab is a treatment approved in 1998 for high-risk children against respiratory infections and is now approved in over 45 countries.
Virus Therapy
Lenacapavir for HIV Prevention
This trial is testing lenacapavir, a drug that may help prevent HIV. It targets people who are at risk of getting HIV. The drug works by stopping the virus from making more copies of itself. Lenacapavir was developed by Gilead Sciences Inc. and has been approved for use in combination with other treatments.
Antiretroviral
DOR/ISL for HIV
This trial is testing a new once-daily pill for HIV-1 infection. The pill contains two drugs, doravirine and islatravir. The trial will compare the new pill to a currently available pill that contains three drugs, bictegravir, emtricitabine, and tenofovir alafenamide. The trial will last 48 weeks and the primary outcome will be the percentage of participants with HIV-1 RNA <50 copies/mL at Week 48.
Virus Therapy
DAS181 for Respiratory Infections
This trial will enroll immunocompromised patients with Lower Tract parainfluenza infection to study the safety and efficacy of an investigational vaccine. A sub-study will also enroll patients with severe COVID-19.
Virus Therapy
Pritelivir vs Foscarnet for Resistant Herpes
This trial compares two treatments for herpes infections in patients with weakened immune systems who do not respond to standard treatment. One treatment is a pill called pritelivir, and the other is a drug called foscarnet. Both aim to stop the virus from replicating and help heal sores. Foscarnet has been used to treat herpes viruses, including drug-resistant cytomegalovirus (CMV) and herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2).
Trials With No Placebo
Monoclonal Antibodies
Lenvatinib + Pembrolizumab for Respiratory Papillomatosis
This trial is studying how well Lenvatinib in combination with Pembrolizumab works in treating patients with human papillomavirus (HPV)-associated recurrent respiratory papillomatosis (RRP).
Trials Offering Remuneration
Virus Therapy
RSV Vaccine for Respiratory Syncytial Virus
This trial tests a new RSV vaccine given as nose drops to help protect against lung infections caused by the RSV virus. It involves healthy children and infants, including those who have and have not had an RSV infection before. The vaccine works by teaching the body to recognize and fight the virus.
Virus Therapy
RSV ΔNS2/Δ1313/I1314L +2 More for Respiratory Syncytial Virus
The purpose of this study is to evaluate the infectivity, safety, and immunogenicity of the recombinant live-attenuated respiratory syncytial virus (RSV) vaccines RSV ΔNS2/Δ1313/I1314L or RSV 276 or placebo when delivered as nose drops to RSV-seronegative infants and children 6 to 24 months of age. This study is a companion study to IMPAACT 2018.
View More Related Trials
Frequently Asked Questions
Introduction to rsv
What are the top hospitals conducting rsv research?
In the realm of respiratory syncytial virus (RSV) clinical trials, several hospitals are leading the charge in finding effective treatments for this common and potentially severe illness. At Cincinnati Children's Hospital Medical Center in Cincinnati, researchers are currently engaged in six active RSV trials, building upon their five previous studies since embarking on their first trial back in 2007. The dedication to understanding and combatting RSV is not limited to a single location, as GSK Investigational Sites across various cities have also made significant contributions. In San Antonio, four ongoing RSV trials are underway alongside seven previously conducted studies that date back to their initial investigation of this condition in 2019. Similarly, at the GSK Investigational Site in Sherbrooke, Quebec, another four active RSV trials complement their track record of seven completed studies since commencing research efforts only last year in 2021.
Expanding further into Texas territory reveals more noteworthy advancements. In Dallas' GSK Investigational Site alone, there are presently four ongoing clinical tests focused on combating RSV while sharing a close collaboration with just five past investigations recorded starting from 2020 onwards. Not too far away lies Fort Myers' own GSK Investigational Site where they join the ranks with an equal number of ongoing rsv inquiries totaling four; though relatively newer than most counterparts given that it was only recently established its presence by initiating first-ever involvement through conducting rsv experimental attempts beginning from early-stage exploration during 2021.
These dynamic hospital centers represent shining beacons of hope for patients affected by respiratory syncytial virus as they tirelessly continue striving towards better preventive measures and treatments against this pervasive infection. Through these collective efforts nationwide - all around different locations - progress is being made step-by-step toward curbing the impact and improving outcomes related to RSV cases which will ultimately lead us closer towards minimizing its burden on global health systems worldwide
Which are the best cities for rsv clinical trials?
In the realm of RSV clinical trials, several cities emerge as prominent hubs for research and development. Los Angeles, California takes the lead with 28 active trials exploring various treatments such as RSVpreF, Oral Lenacapavir (LEN), DOR/ISL, among others. New york, New York follows closely behind with 24 ongoing studies investigating interventions like S-217622 plus standard of care (SOC), Piperacillin-tazobactam, Glecaprevir/Pibrentasvir (GLE/PIB), and more. Baltimore, Maryland also plays a crucial role in advancing RSV treatment options through its 23 active trials focused on BCG TICE Vaccine, Pritelivir, RSV ΔNS2/Δ1313/I1314L Vaccine, and other innovative approaches. These cities contribute significantly to the collective effort in finding effective solutions against RSV while offering individuals affected by this condition access to cutting-edge clinical trials that may improve their health outcomes.
Which are the top treatments for rsv being explored in clinical trials?
Clinical trials are shedding light on potential breakthroughs in the treatment of RSV (respiratory syncytial virus). Among the top contenders is palivizumab, a monoclonal antibody currently being investigated in several promising trials. Another noteworthy candidate is nirsevimab, an investigational fusion protein that has shown promise in early clinical studies. Additionally, there are ongoing trials exploring the efficacy of REGN2222, a potent antiviral antibody against RSV. These treatments hold great potential for revolutionizing the management of RSV and providing hope for those affected by this respiratory infection.
What are the most recent clinical trials for rsv?
Recent clinical trials have brought forth promising advancements in the field of RSV treatment. Notably, Cohort A and RSV_IC_1 groups have undergone Phase 2 trials, showing potential for improved therapeutic options. In addition, a Phase 3 trial has explored the co-administration of RSV+ HZ/su as a means to combat RSV infection. Another Phase 3 study focused on evaluating the effectiveness of low dose RSVpreF against this respiratory virus. Furthermore, Group 2 underwent a Phase 2 trial with encouraging results. These latest clinical trials pave the way towards enhanced management and prevention strategies for RSV infections in patients across different cohorts.
What rsv clinical trials were recently completed?
Recently, several notable clinical trials focusing on RSV (Respiratory Syncytial Virus) have reached completion, showcasing exciting progress in the field. In July 2022, Blue Lake Biotechnology Inc. concluded a trial investigating the CPI-RSV-F Vaccine (BLB-201). Moreover, GlaxoSmithKline wrapped up two important trials: one examining the RSVPreF3 OA investigational vaccine in October 2021 and another exploring the Flu D-QIV vaccine in September 2021. Additionally, their RSV MAT study was completed in August 2021. While MedImmune LLC's MEDI8897 trials were finalized back in July 2019, these collective efforts highlight ongoing research to combat RSV and bring us closer to effective treatments for this respiratory virus.