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ANX007 for Age-Related Macular Degeneration (ARCHER Trial)

Phase 2
Waitlist Available
Research Sponsored by Annexon, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to month 18

Summary

This trial involves injecting ANX007 into the eyes of people with vision loss due to aging. The goal is to slow down the growth of damaged areas in their eyes, potentially preserving their vision.

Who is the study for?
This trial is for people with a specific eye condition called geographic atrophy (GA) due to age-related macular degeneration. Participants must have GA lesions of certain sizes, clear vision within specified limits, and no other major eye diseases or treatments that could interfere with the study. Women must not be pregnant or breastfeeding and should use effective contraception.
What is being tested?
The trial tests if ANX007 injections into the eye can slow down lesion growth in patients with GA secondary to AMD compared to sham injections. The study spans roughly 19 months and aims to inform further development of ANX007 for treating this eye condition.
What are the potential side effects?
While specific side effects are not listed here, intravitreal injections like ANX007 may cause eye discomfort, redness, bleeding inside the eye (hemorrhage), increased pressure in the eye, cataracts, or infection.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to month 18
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to month 18 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
GA lesion growth rate
Secondary study objectives
Best corrected visual acuity (BCVA)
Low-luminance BCVA (LL-BCVA)
Low-luminance visual acuity deficit (LL-VD)
+1 more

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: ANX007 Group 2Experimental Treatment1 Intervention
ANX007 administered every other month
Group II: ANX007 Group 1Experimental Treatment1 Intervention
ANX007 administered every month
Group III: Sham Group 4Placebo Group1 Intervention
Sham injection administered every other month
Group IV: Sham Group 3Placebo Group1 Intervention
Sham injection administered every month
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
ANX007
2021
Completed Phase 2
~280

Find a Location

Who is running the clinical trial?

Annexon, Inc.Lead Sponsor
13 Previous Clinical Trials
1,209 Total Patients Enrolled
Clinical TrialsStudy DirectorAnnexon, Inc.
2,225 Previous Clinical Trials
896,120 Total Patients Enrolled

Media Library

ANX007 (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04656561 — Phase 2
~58 spots leftby Nov 2025
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