Your session is about to expire
← Back to Search
Free Radical Scavenger
MBM-01 (Tempol) for the Treatment of Ataxia Telangiectasia
Phase 2
Waitlist Available
Research Sponsored by Matrix Biomed, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up t25fw will be assessed at baseline, month 3, month 6, and month 9.
Awards & highlights
No Placebo-Only Group
Summary
This trial tests MBM-01, a drug designed to protect and repair cells, in patients with Ataxia Telangiectasia (A-T). These patients lack a protein needed for cell repair, leading to severe health issues. MBM-01 helps reduce cell damage and boosts the body's repair mechanisms.
Eligible Conditions
- Ataxia Telangiectasia
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ t25fw will be assessed at baseline, month 3, month 6, and month 9.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~t25fw will be assessed at baseline, month 3, month 6, and month 9.
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in International Cooperative Ataxia Rating Scale (ICARS)
Secondary study objectives
Change 8-hydroxy-2- Deoxyguanosine (8-OHdG)
Change in GSH/glutathione Disulfide (GSSG) Concentration Ratio
Change in Timed 25 Feet Walking Test (T25FW)
+1 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Cohort 1Experimental Treatment1 Intervention
Group 1 Patients ≥13 years old will receive a total daily dose of 1200 mg/day.
Group 2 - Group 4
Patients 4-12 years old will receive group weight-tiered doses at 17 mg/kg:
Group 2
* Patients aged 4-12 years weighing 15kg to \<25 kg will take 340 mg/day. Group 3
* Patients aged 4-12 years weighing 25kg to \<35 kg will take 510 mg/day. Group 4
* Patients aged 4-12 years weighing ≥35 kg will take 850 mg/day.
Find a Location
Who is running the clinical trial?
Matrix Biomed, Inc.Lead Sponsor
5 Previous Clinical Trials
230 Total Patients Enrolled
The University of Texas Health Science Center, HoustonOTHER
957 Previous Clinical Trials
347,832 Total Patients Enrolled