~27 spots leftby Apr 2026

Efficacy and Safety of Adalimumab in Subjects With Moderately to Severely Active Ulcerative Colitis

Recruiting in Palo Alto (17 mi)
+107 other locations
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 3
Waitlist Available
Sponsor: Abbott
No Placebo Group
Pivotal Trial (Near Approval)
Prior Safety Data

Trial Summary

What is the purpose of this trial?

This was a Phase 3, multicenter, randomized, double-blind, placebo-controlled trial designed to evaluate the efficacy and safety of the human anti-tumor necrosis factor (TNF) monoclonal antibody adalimumab (ADA) in patients with moderately to severely active ulcerative colitis (UC).

Research Team

RB

Roopal B Thakkar, M.D.

Principal Investigator

Abbott

Eligibility Criteria

Inclusion Criteria

Participants >=18 years of age and in good health (Investigator discretion) with a recent stable medical history
Diagnosis of UC for greater than 90 days prior to Baseline
Diagnosis of active UC confirmed by colonoscopy with biopsy or flexible sigmoidoscopy with biopsy during the Screening Period, with exclusion of infection
See 7 more

Treatment Details

Interventions

  • Adalimumab (Monoclonal Antibodies)
  • Placebo (Other)
Participant Groups
2Treatment groups
Experimental Treatment
Group I: placebo groupExperimental Treatment1 Intervention
Group II: adalimumab groupExperimental Treatment1 Intervention

Adalimumab is already approved in Canada, Japan for the following indications:

🇨🇦
Approved in Canada as Humira for:
  • Rheumatoid arthritis
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Crohn's disease
  • Ulcerative colitis
  • Plaque psoriasis
  • Juvenile idiopathic arthritis
🇯🇵
Approved in Japan as Humira for:
  • Rheumatoid arthritis
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Crohn's disease
  • Ulcerative colitis
  • Plaque psoriasis
  • Juvenile idiopathic arthritis

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
Site Ref # / Investigator 3743Nashville, TN
Site Ref # / Investigator 3758Jacksonville, NC
Site Ref # / Investigator 10423Kelowna, Canada
Site Ref # / Investigator 3768Montreal, Canada
More Trial Locations
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Who Is Running the Clinical Trial?

Abbott

Lead Sponsor

Trials
760
Patients Recruited
489,000+