ADU-S100 for Head and Neck Squamous Cell Carcinoma

Phase 2

Waitlist Available

Research Sponsored by Chinook Therapeutics, Inc. (formerly Aduro)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 25 months

Awards & highlights

Summary

ADU-CL-20 is an open-label, multicenter Phase 2 clinical trial to evaluate the efficacy and safety of intratumoral ADU-S100 (also referred to as MIW815) administered with pembrolizumab in the first-line setting. The population will consist of adults with PD-L1 positive recurrent or metastatic HNSCC.

Eligible Conditions

Head and Neck Squamous Cell Carcinoma
Head and Neck Cancers

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 25 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 25 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 25 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Evaluation of Clinical Activity by the Objective Response Rate (ORR; Complete Response [CR] and Partial Response [PR]) Per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1

Trial Design

1Treatment groups

Experimental Treatment

Group I: ADU-S100 and pembrolizumabExperimental Treatment1 Intervention

All eligible subjects will receive intravenous (IV) infusions of pembrolizumab and intratumoral injections of ADU-S100.

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Who is running the clinical trial?

Chinook Therapeutics, Inc. (formerly Aduro)Lead Sponsor

1 Previous Clinical Trials

47 Total Patients Enrolled

Chinook Therapeutics, Inc.Lead Sponsor

8 Previous Clinical Trials

1,016 Total Patients Enrolled

~3 spots leftby Oct 2025

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