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Anti-inflammatory drug

Colchicine 0.5 mg die for Heart Failure (COLpEF Trial)

Phase 2
Waitlist Available
Led By Nadia Bouabdallaoui, MD
Research Sponsored by Montreal Heart Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to 6 months in hs-crp

Summary

This trial tests colchicine, an anti-inflammatory drug, in patients with a specific type of heart failure (HFpEF). The goal is to see if it can reduce inflammation and improve their condition. Colchicine has been used historically to treat inflammatory conditions such as gout and pericarditis.

Eligible Conditions
  • Heart Failure
  • Inflammation and Pain
  • Inflammation
  • Colchicine

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to 6 months in hs-crp
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 6 months in hs-crp for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in hs-CRP (C reactive protein)
Secondary study objectives
Change in circulating biomarkers of hemodynamic stress
Change in circulating biomarkers of myocardial injury
Change in functional status and symptoms
+1 more
Other study objectives
Safety endpoints

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: Colchicine 0.5 mg dieActive Control1 Intervention
Colchicine 0.5 mg die
Group II: Colchicine 0.5 mg bidActive Control1 Intervention
Colchicine 0.5 mg bid
Group III: PlaceboPlacebo Group1 Intervention
Placebo

Find a Location

Who is running the clinical trial?

Montreal Heart InstituteLead Sponsor
123 Previous Clinical Trials
80,746 Total Patients Enrolled
24 Trials studying Heart Failure
10,450 Patients Enrolled for Heart Failure
Nadia Bouabdallaoui, MDPrincipal InvestigatorMontreal Heart Institute
~4 spots leftby Nov 2025
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