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Small Molecule

Branaplam for Huntington Disease (VIBRANT-HD Trial)

Phase 2
Waitlist Available
Research Sponsored by Novartis Pharmaceuticals
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline up to approximately 2 years
Awards & highlights

VIBRANT-HD Trial Summary

This trial is testing a new drug to see if it can lower the amount of a harmful protein in people with Huntington's Disease.

Eligible Conditions
  • Huntington Disease

VIBRANT-HD Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to approximately 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to approximately 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of treatment emergent adverse events and serious adverse events
Reduction (%) of mHTT protein in cerebrospinal fluid (CSF)
Secondary outcome measures
Area under the curve (AUC) of UFB112 in plasma
Area under the curve (AUC) of branaplam in plasma
Change from baseline in Ventricular Volume, Caudate Volume and Total Brain Volume
+16 more

VIBRANT-HD Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment Arm C or X or YExperimental Treatment1 Intervention
(C) Branaplam 154 mg oral solution once weekly, OR (X) Branaplam 84 mg oral solution once weekly OR (Y) Branaplam 28 mg oral solution once weekly
Group II: Treatment Arm BExperimental Treatment1 Intervention
Branaplam 112 mg oral solution once weekly
Group III: Treatment Arm AExperimental Treatment1 Intervention
Branaplam 56 mg oral solution once weekly
Group IV: PlaceboPlacebo Group1 Intervention
Matching placebo oral solution once weekly
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Branaplam
2021
Completed Phase 2
~30

Find a Location

Who is running the clinical trial?

Novartis PharmaceuticalsLead Sponsor
2,866 Previous Clinical Trials
4,199,300 Total Patients Enrolled
1 Trials studying Huntington Disease
44 Patients Enrolled for Huntington Disease

Media Library

Huntington Disease Research Study Groups: Treatment Arm A, Treatment Arm B, Treatment Arm C or X or Y, Placebo
Huntington Disease Clinical Trial 2023: Branaplam Highlights & Side Effects. Trial Name: NCT05111249 — Phase 2
~8 spots leftby Jun 2025
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