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Dexmedetomidine / Ketamine / Lidocaine for Temporomandibular Joint Disorder

Phase 2
Recruiting
Led By Jingping Wang, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 48 hours postoperatively
Awards & highlights

Study Summary

This trial will test whether patients who have surgery on their temporomandibular joint (TMJ) recover better when they do not receive opioids during anesthesia.

Eligible Conditions
  • Temporomandibular Joint Disorder (TMJ Disorder)

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48 hours postoperatively
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48 hours postoperatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain Score
Secondary outcome measures
Incidence of Opioid Related Adverse Effects
Length of Stay
Pain Satisfaction
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Opioid-free AnesthesiaExperimental Treatment1 Intervention
Patients in this arm will not receiving opioids but the total intravenous anesthetic during surgery. Patients in this group will receive an infusion of lidocaine, ketamine, or dexmedetomidine supplemented with other intravenous analgesics and intravenous and inhaled anesthetics.
Group II: Standard AnesthesiaActive Control1 Intervention
Patients in this arm will undergo the standard of care and receive opioids as part of their anesthetic regimen.

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Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,943 Previous Clinical Trials
13,200,929 Total Patients Enrolled
Jingping Wang, MDPrincipal InvestigatorMassachusetts General Hospital
~15 spots leftby Jun 2025
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