~2 spots leftby Apr 2026

IMG-7289 for Essential Thrombocythemia

Recruiting in Palo Alto (17 mi)
Overseen byZohra Nooruddin, MD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: The University of Texas Health Science Center at San Antonio
No Placebo Group
Prior Safety Data

Trial Summary

What is the purpose of this trial?

This is a single-center, open-label investigator-initiated trial evaluating the effects of IMG-7289 administered orally once daily in patients with essential thrombocythemia.

Eligibility Criteria

Adults diagnosed with Essential Thrombocythemia who have high platelet counts despite hydroxyurea treatment, can swallow capsules, and will use contraception. Excluded are those with unresolved toxicities from past treatments, active infections including HIV/hepatitis, bleeding risks, pregnancy/breastfeeding plans within six months or current breastfeeding.

Inclusion Criteria

I can swallow pills.
Peripheral blast count <10% pre-dose Day 1
I agree not to father a child or donate sperm for a month after my last dose.
See 15 more

Exclusion Criteria

I need considerable assistance and am unable to carry out any work activities.
I have had more than 3 blood transfusions in the last 6 months or any transfusion in the last 4 weeks.
You have signs that show you might have a higher chance of bleeding, such as:
See 10 more

Treatment Details

Interventions

  • IMG-7289 (LSD1 Inhibitor)
Trial OverviewThe trial is testing the oral drug IMG-7289 for patients with Essential Thrombocythemia. It's an open-label study where all participants know they're receiving the medication to see how it affects their condition.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: IMG-7289Experimental Treatment1 Intervention

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
Mays Cancer CenterSan Antonio, TX
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Who Is Running the Clinical Trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
Imago BioSciences,Inc.Industry Sponsor
Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA)Industry Sponsor

References