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Statins

Atorvastatin for the Treatment of Retinal Vein Occlusion (ATORVO Trial)

Phase 3
Waitlist Available
Led By Joel G Ray, MD MSc
Research Sponsored by University of Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved
Pivotal Trial
Approved for 40 Other Conditions

Summary

The ATORVO study is designed to determine whether atorvastatin (Lipitor) can improve vision, when compared to placebo

Eligible Conditions
  • Central Retinal Vein Occlusion
  • Intrapericardial Thrombosis
  • Eye stroke
  • Blood Clot
  • Branch Retinal Vein Occlusion
  • Retinal Vein Occlusion

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2014 Phase 3 trial • 58 Patients • NCT02084069
3%
Postoperative bleeding
100%
80%
60%
40%
20%
0%
Study treatment Arm
Treatment
Control

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
Approved for 40 Other Conditions
This treatment demonstrated efficacy for 40 other conditions.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: AExperimental Treatment1 Intervention
Atorvastatin 80 mg orally once daily for 24 weeks
Group II: PPlacebo Group1 Intervention
Placebo tablet orally once daily for 24 weeks
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Atorvastatin
FDA approved

Find a Location

Who is running the clinical trial?

PfizerIndustry Sponsor
4,675 Previous Clinical Trials
28,717,002 Total Patients Enrolled
Unity Health TorontoOTHER
562 Previous Clinical Trials
453,771 Total Patients Enrolled
Ontario Association of OptometristsOTHER
University of TorontoLead Sponsor
725 Previous Clinical Trials
1,115,516 Total Patients Enrolled
Canadian Heart Research CentreOTHER
9 Previous Clinical Trials
7,584 Total Patients Enrolled
Toronto Ophthalmological SocietyUNKNOWN
Joel G Ray, MD MScPrincipal InvestigatorSt. Michael's Hospital, University of Toronto
David Wong, MDPrincipal InvestigatorSt. Michael's Hospital, University of Toronto
1 Previous Clinical Trials
159 Total Patients Enrolled
~10 spots leftby Jan 2026
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