Methazolamide for Glaucoma

Recruiting in Palo Alto (17 mi)

Overseen byMalik Y. Kahook, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: University of Colorado, Denver

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?The purpose of this study is to evaluate the effect of methazolamide, 25 mg or 50 mg tablets once a day for a week than twice a day for a week, on lowering intraocular pressure and the safety of methazolamide.

Eligibility Criteria

This trial is for English-reading men and women aged 50 to 90 with open-angle glaucoma in both eyes. It's not for those with other types of glaucoma, severe or end-stage glaucoma, or if they are pregnant or breastfeeding.

Inclusion Criteria

I am between 50 and 90 years old.

I have been diagnosed with open angle glaucoma in both eyes.

Ability to read and write in English

Exclusion Criteria

Pregnant or breast-feeding women

My glaucoma is severe, with significant vision field loss.

I have a type of glaucoma that is not open-angle glaucoma.

Participant Groups

The study tests methazolamide tablets at doses of 25 mg and 50 mg to lower eye pressure in glaucoma patients. Participants will take one dose daily for a week, then twice daily for another week to assess effectiveness and safety.

2Treatment groups

Active Control

Group I: Methazolamide 25 mgActive Control1 Intervention

Once a day \[q.d\] in the morning for 1 week, Twice a day \[b.i.d.\] in the morning and evening for 1 week

Group II: Methazolamide 50 mgActive Control1 Intervention

Once a day \[q.d\] in the morning for 1 week, Twice a day \[b.i.d.\] in the morning and evening for 1 week