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Corticosteroid

Group 1: Shoulder Block using Exparel for Postoperative Pain

Phase 4
Waitlist Available
Research Sponsored by Rothman Institute Orthopaedics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Participants having a primary rotator cuff repair
* Age 18 and older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 14 days
Awards & highlights

Summary

Effective and safe control of pain after shoulder surgery is an important component of the post-surgical process. Patients who are comfortable in the early period after surgery are more satisfied with their experience and are better able to participate in rehabilitation exercises during their stay in the hospital. As surgeons and health care systems in the United States find themselves in the middle of an opioid epidemic, it is necessary to discover different options to provide patients pain relief that are both effective and safe in an effort to decrease the amount of pain medication used.

Who is the study for?
This trial is for individuals with rotator cuff injuries who have undergone surgery. It's aimed at those seeking effective postoperative pain management without relying heavily on opioids, which can be addictive.
What is being tested?
The study is testing the effectiveness of two different medications for managing pain after shoulder surgery: Dexamethasone and Liposomal bupivacaine (Exparel), compared to a standard treatment using Bupivacaine Hcl.
What are the potential side effects?
Possible side effects may include discomfort or pain at the injection site, nausea, headache, dizziness, and potential allergic reactions. Long-term use of steroids like Dexamethasone could lead to more serious side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~14 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 14 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Postoperative narcotic medication use
Postoperative pain levels

Trial Design

2Treatment groups
Active Control
Group I: Group 1: Shoulder Block using ExparelActive Control2 Interventions
Participants having rotator cuff repair surgery will receive Liposomal bupivacaine (Exparel) + bupivacaine given in their shoulder block before surgery.
Group II: Group 2: Shoulder Block using Exparel + DexamethasoneActive Control3 Interventions
Participants having rotator cuff repair surgery will receive Liposomal bupivacaine (Exparel) + Dexamethasone + bupivacaine given in their shoulder block before surgery.

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Who is running the clinical trial?

Rothman Institute OrthopaedicsLead Sponsor
123 Previous Clinical Trials
21,704 Total Patients Enrolled
3 Trials studying Postoperative Pain
523 Patients Enrolled for Postoperative Pain
~84 spots leftby Aug 2025
Unbiased ResultsWe believe in providing patients with all the options.
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