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Enhanced Usual Care for Opioid Cessation (STOP Trial)

N/A
Waitlist Available
Led By Jennifer Hah, MD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Scheduled for total hip, knee, or shoulder replacement
Be older than 18 years old
Must not have
Elevated suicidality
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 year
Awards & highlights
No Placebo-Only Group

Summary

This trial will compare two methods for helping people quit opioids after hip or knee surgery.

Who is the study for?
This trial is for English-speaking adults who are planning to undergo hip, knee, or shoulder replacement surgery and have used opioids before and after the operation. They should be willing to complete surveys and not currently under a pain specialist's care. People with high suicide risk, pregnant individuals, those unable to do assessments, or in another perioperative study can't join.
What is being tested?
The study compares two approaches: 'enhanced usual care' versus 'motivational interviewing with guided opioid tapering support', aiming to help patients stop using opioids after their joint replacement surgeries.
What are the potential side effects?
While specific side effects aren't listed for motivational interviewing or enhanced usual care, participants may experience discomfort from discussing personal issues related to opioid use during interviews.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am scheduled for a hip, knee, or shoulder replacement surgery.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have had serious thoughts about harming myself.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Time to Opioid Cessation
Secondary study objectives
Opioid Misuse

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Motivational Interviewing and Guided Opioid Tapering SupportExperimental Treatment1 Intervention
Group II: Enhanced Usual CareExperimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Enhanced Usual Care
2019
Completed Phase 3
~8400

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)NIH
2,586 Previous Clinical Trials
3,328,080 Total Patients Enrolled
Stanford UniversityLead Sponsor
2,472 Previous Clinical Trials
17,501,368 Total Patients Enrolled
1 Trials studying Opioid Cessation
104 Patients Enrolled for Opioid Cessation
Jennifer Hah, MDPrincipal InvestigatorStanford University
~71 spots leftby Nov 2025
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