Radiation Therapy Techniques for Lung Cancer

Recruiting in Palo Alto (17 mi)

Overseen byJohn Heinzerling, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Atrium Health

No Placebo Group

Trial Summary

What is the purpose of this trial?This is a pilot study designed to to provide data and experience comparing two different techniques of breath hold SBRT treatments. The first technique will include SGRT, but with the assistance of implanted fiducials. Subjects will be treated with a breath hold technique utilizing SGRT, but will also be imaged during treatment with fiducial match. The second technique will utilize SGRT for breath hold treatments without the assistance of implanted fiducials/continuous imaging.

Eligibility Criteria

This trial is for adults over 18 with certain types of lung cancer or tumors that move when they breathe. They must be able to follow the study plan and use effective birth control if needed. People can't join if they've had chest radiation before, have an active lung infection or pneumonitis, or were treated for pneumonitis within the last 15 days.

Inclusion Criteria

I am currently on chemotherapy or other treatments but can stop them for SBRT.

My tumor is 7 cm or smaller, confirmed or suspected to be cancer.

I can take care of myself but might not be able to do heavy physical work.

+6 more

Exclusion Criteria

I am currently being treated for a lung infection or inflammation.

I have had radiation to the chest in the same area before.

I was treated for lung inflammation from a drug or therapy within the last 15 days.

Participant Groups

The study compares two ways to do SBRT (a type of radiation therapy) during breath holds for treating lung issues. One way uses SGRT with implanted markers called fiducials; the other just uses SGRT without these markers.

3Treatment groups

Experimental Treatment

Group I: Group 3Experimental Treatment1 Intervention

Breath hold SBRT with SGRT in combination with implanted fiducials

Group II: Group 2Experimental Treatment1 Intervention

Breath hold SBRT with SGRT

Group III: Group 1Experimental Treatment1 Intervention

Freebreathing SBRT with SGRT