Stereotactic Body Radiation Therapy for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores two methods to guide radiation therapy for prostate cancer: CT-guided Stereotactic Body Radiation Therapy and MRI-guided Stereotactic Body Radiation Therapy. Both methods help doctors target prostate cancer with radiation, but the study aims to determine if MRI guidance provides additional benefits over CT guidance. The trial includes men with prostate cancer confined to the prostate and nearby areas. Participants should not have undergone certain prostate treatments, such as cryosurgery or other radiation therapies, and must be comfortable with MRI scans. As a Phase 2 trial, this research focuses on assessing the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to significant advancements in prostate cancer treatment.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that both CT-guided and MRI-guided stereotactic body radiation therapy (SBRT) are safe for treating prostate cancer. Studies have found SBRT to be a standard and well-tolerated option for patients with varying levels of prostate cancer risk.
For CT-guided SBRT, research indicates it can safely deliver the necessary doses. Its effective use in treating other types of cancer further supports its safety for prostate cancer.
MRI-guided SBRT has also demonstrated promising safety results. Studies suggest it can significantly reduce immediate side effects compared to CT-guided treatment, leading to fewer short-term side effects for patients.
Overall, both treatments are generally well-tolerated and considered safe based on existing research. However, individual experiences with side effects may vary.12345Why are researchers excited about this trial?
Researchers are excited about these treatments because CT-guided and MRI-guided Stereotactic Body Radiation Therapy (SBRT) offer a more precise approach to targeting prostate cancer compared to traditional radiation therapies. Unlike standard treatments, which may affect surrounding healthy tissue, these methods aim to deliver high doses of radiation directly to the tumor with pinpoint accuracy. MRI-guided SBRT takes it a step further by using real-time imaging to adapt to changes in the tumor's position, potentially improving outcomes and reducing side effects. These advancements could lead to more effective treatments with fewer sessions, enhancing patient comfort and convenience.
What evidence suggests that this trial's treatments could be effective for prostate cancer?
This trial will compare two methods of stereotactic body radiation therapy (SBRT) for treating prostate cancer. Research has shown that CT-guided SBRT, which participants in Group I will receive, works well for treating prostate cancer. In one study, patients who received this treatment had good results after five years. This method safely delivers high doses of radiation directly to the prostate.
MRI-guided SBRT, which participants in Group II will receive, is a newer option that also looks promising. Studies suggest it allows for more precise targeting of tumors, potentially improving treatment results. MRI guidance helps doctors see the cancer more clearly, making radiation delivery more accurate.
Both treatments in this trial focus on delivering precise radiation to the cancer while reducing harm to nearby healthy tissue.23567Who Is on the Research Team?
Amar Kishan
Principal Investigator
UCLA / Jonsson Comprehensive Cancer Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo 5 fractions of CT-guided or MRI-guided SBRT over 14 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- CT-guided Stereotactic Body Radiation Therapy
- MRI-guided Stereotactic Body Radiation Therapy
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Patients undergo 5 fractions of MRI-guided SBRT over 14 days in the absence of disease progression or unacceptable toxicity.
Patients undergo 5 fractions of CT-guided SBRT over 14 days in the absence of disease progression or unacceptable toxicity.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Jonsson Comprehensive Cancer Center
Lead Sponsor
Citations
Five-year outcomes of stereotactic body radiation therapy ...
In this retrospective study, 133 PCa patients in our center were treated by SBRT with CyberKnife (Accuray Inc., Sunnyvale, USA) from October 2012 to July 2019.
CT-guided online adaptive stereotactic body radiotherapy ...
We hypothesized that CT-guided online adaptive radiotherapy (OART) can account for interfraction movement of OARs and allow for safe delivery of ablative doses.
Stereotactic Body Radiation Therapy: A Radiosurgery ...
A radiosurgery society guide to the treatment of localized prostate cancer illustrated by challenging cases.
CT-guided Stereotactic Body Radiation Therapy and MRI ...
This phase III trial studies compares CT-guided stereotactic body radiation therapy and MRI-guided stereotactic body radiation therapy (SBRT) in treating ...
Extended Field Spine Stereotactic Body Radiation Therapy ...
This study aimed to determine whether online adaptive radiation therapy (ART) with a CT-guided system can safely permit SBRT treatment over extended consecutive ...
Evaluation of Safety of Stereotactic Body Radiotherapy for the ...
Standard ablative radiation schedules appear to be safe for patients with oligometastatic disease with 3 to 4 metastases or 2 metastases in close proximity to ...
SBRT for Prostate Cancer - Radiation Oncology
SBRT is considered a standard of care option for any patient with low through very-high risk prostate cancer who is considering radiation therapy.
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