Dialectical Behavior Therapy for Youth with Bipolar Disorder (DB1 Trial)
Recruiting in Palo Alto (17 mi)
Age: < 65
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Centre for Addiction and Mental Health
No Placebo Group
Trial Summary
What is the purpose of this trial?Dialectical behavior therapy (DBT) will be conducted over 1 year in youth with and/or at familial risk for bipolar disorder (BD). DBT will be divided into two modalities: 1) DBT skills training; and 2) DBT individual therapy sessions. Skills training sessions will incorporate the 5 standard adolescent DBT modules: mindfulness skills, emotion regulation skills, distress tolerance skills, interpersonal skills, and walking the middle path skills and an additional module on psychoeducation about DBT and BD. This study seeks to build upon the knowledge base in this area by offering DBT to youth with and/or at familial risk for BD with an emphasis on predictors and mediators of treatment outcomes.
How is Dialectical Behavior Therapy (DBT) different from other treatments for bipolar disorder in youth?
Dialectical Behavior Therapy (DBT) is unique because it combines cognitive-behavioral techniques with mindfulness practices to help manage emotions and behaviors, which is particularly beneficial for adolescents with bipolar disorder who experience intense mood swings. Unlike standard treatments, DBT focuses on teaching skills to improve emotional regulation and interpersonal effectiveness, which can be especially helpful for managing the mood symptoms associated with bipolar disorder.
12346Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, if you have Bipolar Disorder type I, you must be taking at least one mood-stabilizing medication to participate.
Is Dialectical Behavior Therapy (DBT) safe for adolescents with bipolar disorder?
Research on Dialectical Behavior Therapy (DBT) for adolescents with bipolar disorder suggests it is generally safe, as it has been used in various studies without significant safety concerns. DBT is a well-established therapy for emotional and behavioral issues, and while its effectiveness for bipolar disorder is still being studied, safety data from these trials indicate it is safe for use in humans.
12356What data supports the effectiveness of the treatment Dialectical Behavior Therapy for youth with bipolar disorder?
Research suggests that Dialectical Behavior Therapy (DBT) can help reduce depressive symptoms in adolescents, and it has been effective in treating mood-related issues in other conditions like borderline personality disorder. While specific data on DBT for bipolar disorder is limited, these findings indicate potential benefits for mood stabilization in youth with bipolar disorder.
12346Eligibility Criteria
This trial is for English-speaking youth aged 13 to nearly 24, who either have bipolar disorder and are on mood stabilizers or have a family history of it. They must be seeing a CAMH psychiatrist regularly and have a history of suicide attempts, self-harm, severe emotional distress, or impulsive behaviors.Inclusion Criteria
I have been diagnosed with bipolar disorder, or I have a close relative with it.
Exclusion Criteria
I have a life-threatening condition that needs immediate treatment.
Participant Groups
The study tests Dialectical Behavior Therapy (DBT) over one year for young people with or at risk for bipolar disorder. It includes skills training in mindfulness, emotion regulation, distress tolerance, interpersonal effectiveness and psychoeducation about DBT and BD.
1Treatment groups
Experimental Treatment
Group I: Youth with and/or at familial risk for bipolar disorderExperimental Treatment1 Intervention
60 youth aged 13 to 23 with and/or at familial risk for bipolar disorder will be enrolled in the dialectical behavioral therapy intervention.
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
Centre for Addiction and Mental HealthToronto, Canada
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Who is running the clinical trial?
Centre for Addiction and Mental HealthLead Sponsor
References
Dialectical behavior therapy for adolescents with bipolar disorder: a 1-year open trial. [2018]To describe an adapted version of dialectical behavior therapy for adolescents with bipolar disorder.
A randomized, controlled, pilot study of dialectical behavior therapy skills in a psychoeducational group for individuals with bipolar disorder. [2018]Bipolar disorder (BD) is a chronic and disabling psychiatric disorder characterized by recurrent episodes of mania/hypomania and depression. Dialectical behavior therapy (DBT) techniques have been shown to effectively treat borderline personality disorder, a condition also marked by prominent affective disturbances. The utility of DBT techniques in treating BD has been largely unexplored. The purpose of this research was to conduct a pilot study of a DBT-based psychoeducational group (BDG) in treating euthymic, depressed, or hypomanic Bipolar I or II patients.
Dialectical behavior therapy for adolescents with bipolar disorder: results from a pilot randomized trial. [2022]The purpose of this study was to conduct a pilot randomized trial of dialectical behavior therapy (DBT) versus psychosocial treatment as usual (TAU) for adolescents diagnosed with bipolar disorder (BP).
Dialectical Behavior Therapy Decreases Depressive Symptoms Among Adolescents in an Acute-Care Inpatient Unit. [2021]Objective: Research has shown that dialectical behavior therapy (DBT) is an effective treatment modality to decrease suicidal ideation, incidents of nonsuicidal self-injurious behavior, and suicide attempts in an adolescent outpatient population. However, research on the impact of DBT on depressive and manic symptoms for adolescents and within an inpatient setting is limited. The purpose of this study is to examine whether DBT significantly decreases depressive and manic symptoms compared with treatment as usual (TAU) for inpatient adolescents. Method: We conducted a retrospective chart review for adolescents receiving inpatient DBT and for a historical control group on the same unit before DBT (i.e., TAU). Group differences for continuous outcomes were analyzed using analysis of covariance (ANCOVA), where discharge scores for Hamilton Depression Rating Scale (HAMD), Young Mania Rating Scale (YMRS), Clinical Global Impressions-Severity for Symptoms (CGI-S), and Dynamic Appraisal of Situational Aggression (DASA) were predicted by treatment condition (i.e., DBT and TAU) while co-varying for admission scores and using a t test for CGI-Improvement (CGI-I) in functioning, which was administered upon discharge. Results: Patients who received DBT had significantly lower HAMD scores, F(1, 409) = 5.272, p = 0.022, ηp2 = 0.013, and lower CGI-I scores, t(596) = 2.50, p = 0.00 upon discharge when controlling for admission scores, compared with patients who received TAU. ANCOVAs showed no significant differences on the YMRS, CGI-S, or DASA between the DBT and TAU groups. Conclusion: DBT on an acute-care inpatient unit for adolescents seems to significantly decrease depressive symptoms during a relatively short period of time compared with TAU. DBT may be an effective treatment modality to decrease depressive symptoms for acute-care inpatient units for adolescents.
Innovations in Practice: Dialectical behaviour therapy for adolescents: multisite implementation and evaluation of a 16-week programme in a public community mental health setting. [2020]Dialectical behaviour therapy for adolescents (DBT-A) is an intervention with a growing evidence base for treating adolescents with emotional and behavioural dysregulation. This study describes the implementation and effectiveness of 16-week DBT-A across multiple sites in publicly funded child/adolescent mental health services (CAMHS) in Ireland.
A systematic review on the effectiveness of dialectical behavior therapy for improving mood symptoms in bipolar disorders. [2023]Evidence-based psychotherapies available to treat patients with bipolar disorders (BD) are limited. Dialectical behavior therapy (DBT) may target several common symptoms of BD. We conducted a systematic review on the efficacy of DBT for mood symptoms in patients with BD. The systematic search used key words related to DBT and BD in Medline, Embase, PsycInfo, CINAHL, and Cochrane Library databases from 1980 to April 1st, 2022. We included studies that enrolled patients with a BD I or II diagnosis (DSM or ICD), age 12 and older who received a DBT-based intervention. Studies reviewed were clinical trials including observational studies that reported at least one outcome related to BD mood symptoms or severity. We did not exclude based upon psychiatric or physical co-morbidity.