Neuromodulation for Depression

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Massachusetts General Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?

The specific aim of this proposed study is to investigate the feasibility and therapeutic potential of LIFUP in changing negative cognition in depression. Specifically, the investigators will study if modulating DMN activity can change maladaptive mind-wandering. The investigators hypothesize that DOWN-modulation of the posterior cingulate cortex (PCC), a key DMN node, will decrease DMN resting state functional connectivity, perfusion, and activation during a cognitive-affective task (description below). The investigators also hypothesize that DOWN-modulation of the PCC will be associated with decreased mind-wandering and increased mindfulness. Finally, the investigators hypothesize that the opposite will be true for UP-modulation of the PCC.

Research Team

Eligibility Criteria

This trial is for right-handed adults aged 18-64 with a current diagnosis of depression. Participants must have normal or corrected-to-normal vision and hearing, without significant medical illnesses, neurological disorders, or MRI scan contraindications like metal implants.

Inclusion Criteria

My vision and hearing are normal, or corrected to be normal.

I am either male or female.

I am currently diagnosed with depression.

See 2 more

Exclusion Criteria

I have a serious illness or brain disorder.

You cannot have an MRI scan if you have metal implants, are claustrophobic or weigh more than 250 pounds.

I have never had a mood disorder.

Treatment Details

Interventions

BrainSonix Pulsar 1002 (Neuromodulation)

Trial OverviewThe study tests the BrainSonix Pulsar 1002's ability to modulate brain activity in the posterior cingulate cortex (PCC) to potentially reduce negative mind-wandering associated with depression. It will explore if altering PCC activity can affect mindfulness and cognitive-affective tasks.

Participant Groups

2Treatment groups

Active Control

Placebo Group

Group I: Active LIFUPActive Control1 Intervention

All participants will receive active modulation of the posterior cingulate cortex (PCC) during Visit 3 or 4 (order counterbalanced).

Group II: Sham LIFUPPlacebo Group1 Intervention

All participants will receive sham modulation of the posterior cingulate cortex (PCC) during Visit 3 or 4 (order counterbalanced).