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Positive Processes and Transition to Health (PATH) for Post-Traumatic Stress Disorder (PATH Trial)

N/A

Waitlist Available

Led By Norah C Feeny, PhD

Research Sponsored by Case Western Reserve University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up score at 6 weeks (immediately post treatment)

Awards & highlights

No Placebo-Only Group

Summary

This trial tests PATH therapy, which helps adults with PTSD or depression from major life events. PATH aims to change negative thoughts, encourage facing problems, and promote positive experiences.

Eligible Conditions

Depression
Post-Traumatic Stress Disorder

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ score at 6 weeks (immediately post treatment)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~score at 6 weeks (immediately post treatment)

This trial's timeline: 3 weeks for screening, Varies for treatment, and score at 6 weeks (immediately post treatment) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Affective Updating Task (Pe et al., 2013; Pe, Raes, et al., 2013)

Idiographic Behavioral Approach Task

Probabilistic Reward Task (Pizzagalli et al., 2005)

Secondary study objectives

Mental Depression

Posttraumatic Cognitions Inventory (Foa et al., 1999)

Snaith-Hamilton Pleasure Scale (Snaith et al., 1995)

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: receive PATH therapyExperimental Treatment1 Intervention

PATH includes six 60-90 min, weekly sessions, with two booster sessions for partial responders. Session 1 provides the PATH rationale and a review of life events (PATH of life: negative and positive). A rationale for an explicit focus on positive events/emotions will be provided. Sessions 2-4 focus on a verbal narrative of the destabilizing life event, reminiscence and processing of a major positive life event, and real-life practice to enact what was taught. Sessions 5 focuses on constructive processing and provides opportunity for integration and consolidation of learning. Session 6 focuses on future negative and positive events to promote application of new learning and resilience. Booster sessions focus on positive and negative life events since the last session and adaptive processes (constructive processing, approach, and reward). All sessions will include cultivation and elaboration of positive emotions to promote engagement and to build on the benefits of positive emotions.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Positive Processes and Transition to Health (PATH)

2021

N/A

~50

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