Stem Cell Regeneration for Gum Recession

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Alabama at Birmingham

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial uses special cells from the gums that can turn into different types of tissues. It targets patients undergoing gum grafting surgery. These cells help repair and regenerate damaged tissues by transforming into the needed cell types.

Eligibility Criteria

This trial is for English-speaking patients at the UAB Dental School with healthy teeth and gums who need a soft tissue graft due to mild to moderate gum recession. They must be able to maintain good oral hygiene, not be pregnant or breastfeeding, and not have had previous palate surgery.

Inclusion Criteria

My gums and teeth are healthy where I need treatment.

I have never had tissue taken from the roof of my mouth.

I need a gum graft for my teeth with mild to moderate recession.

Exclusion Criteria

I have gum disease where I will receive treatment.

I have severe gum recession.

I am taking medication that can cause gum swelling.

Participant Groups

The study aims to compare the regenerative abilities of mesenchymal stem cells taken from two areas in the mouth's roof (palate) - near the front (premolar) and back (molar). It will help optimize how these cells are used in repairing tissues like bone and gums.

2Treatment groups

Experimental Treatment

Group I: Progenitor Potential at Premolar siteExperimental Treatment1 Intervention

Harvested tissue from the front (premolar) part of the palate will be used to extract the gingival mesenchymal cells to test their progenitor potential to differentiate into multiple cell lineage.

Group II: Progenitor Potential at Molar siteExperimental Treatment1 Intervention

Harvested tissue from the back (molar) part of the palate will be used to extract the gingival mesenchymal cells to test their progenitor potential to differentiate into multiple cell lineage.