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TMS for Depression and Anxiety

N/A

Waitlist Available

Research Sponsored by Jing Jiang

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age between 18 and 65 years

Patients with a diagnosis of major depressive disorder and/or general anxiety disorder

Must not have

Diagnosis of epilepsy or seizure disorder

Age below 18 or above 65 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 10 minutes

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to understand how transcranial magnetic stimulation (TMS) affects the brain in both healthy individuals and those with depression and anxiety. They will recruit an equal number of male and female participants

Who is the study for?

This trial is for men and women aged 18-65, both healthy individuals and those experiencing symptoms of depression or anxiety. Participants must be able to complete cognitive tests and undergo brain scans. Specific criteria for joining or being excluded from the study are not provided.

What is being tested?

The study investigates how single-pulse TMS affects the brain immediately and how repetitive TMS can have long-term effects, using fMRI scans. It also explores whether these effects can predict negative emotions like depression or anxiety in participants.

What are the potential side effects?

While specific side effects are not listed, typical TMS-related side effects may include headache, scalp discomfort at the stimulation site, lightheadedness, or a small risk of seizure. The fMRI procedure is non-invasive but may cause discomfort due to loud noises or claustrophobia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 65 years old.

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I have been diagnosed with major depression or anxiety.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have been diagnosed with epilepsy or a seizure disorder.

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I am either younger than 18 or older than 65.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 10 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 10 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 10 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Difference in TBS Modulation Effect Across Comparison Groups

Pre and Post TBS Modulation Effect Comparison

Secondary study objectives

TMS Effects with Neurocognitive and Emotion Functions

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: spTMS-TBS-spTMSExperimental Treatment1 Intervention

This is an open-label, single-arm study. The intervention will be delivered in spTMS-TBS-spTMS order to the dorsolateral prefrontal cortex (dlPFC) and vertex for each participant as described in the "Interventions" section. The order of the stimulation sites will be counterbalanced across participants.

0 / 4Eligibility criteria met