Low vs High Sodium Diet for High Blood Pressure
Trial Summary
What is the purpose of this trial?
Salt sensitive hypertension is a significant health problem worldwide and a primary modifiable risk factor for renal, cardiovascular, and cerebrovascular diseases. Yet, the underlying mechanisms remain poorly understood. The proposed study determines how renal oxygenation and substrate metabolism differs between individuals with and without salt sensitivity, with the ultimate goal of identifying mechanisms, diagnostic criteria, and treatment strategies for salt sensitive hypertension.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you use glucocorticoids or anti-platelet and anticoagulant agents like aspirin.
What data supports the effectiveness of the treatment for high blood pressure?
Is a low or high sodium diet safe for humans?
Research suggests that reducing sodium intake can lower blood pressure, which is generally safe and beneficial for people with high blood pressure. However, there is limited evidence on the long-term safety of low sodium diets in terms of overall health outcomes like mortality and morbidity, and more studies are needed to confirm these effects.678910
How does the low vs high sodium diet treatment for high blood pressure differ from other treatments?
Eligibility Criteria
This trial is for English-speaking individuals with blood pressure levels indicating elevated BP or Stage 1 hypertension, as per the 2017 ACC/AHA guidelines. It's not suitable for those with normal or severe high blood pressure, diabetes, heart failure, liver cirrhosis, electrolyte issues, kidney disease, certain medication use (like glucocorticoids), pregnant/nursing women, bleeding disorders, heavy daily salt intake (>6000 mg/day), metallic implants presence in body including pacemakers.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Low Sodium Diet
Participants follow a low sodium diet (1200 mg/day) for two weeks with food logs and dietary assessments
Wash-out
Participants undergo a wash-out period between diet phases
High Sodium Diet
Participants follow a high sodium diet (>4200 mg/day) for two weeks with sodium chloride supplementation if needed
Follow-up
Participants are monitored for changes in renal oxygenation and metabolites after diet interventions
Treatment Details
Interventions
- high sodium diet (Behavioural Intervention)
- Low sodium diet (Behavioural Intervention)