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Cooling Strategies for Hyperthermia in the Elderly

N/A

Recruiting

Research Sponsored by University of Texas Southwestern Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within 60 minutes before each simulated heat wave exposure and during each simulated heat wave exposure (up to 3 hours)

Awards & highlights

No Placebo-Only Group

Summary

This trial studies how cooling helps reduce heart strain from summer heat waves in elderly people.

Who is the study for?

This trial is for people aged 65 or older who are generally healthy, without significant medical issues based on a thorough check-up. It's not open to those with certain heart problems, a BMI of 31 or higher, chronic conditions needing ongoing treatment, known heart disease, current smokers or those who quit within the last three years.

What is being tested?

The study is looking at how different cooling methods like fans and water sprays can help reduce heat-related cardiovascular stress in elderly individuals during heat waves. Some participants will use just a fan, others just a spray, some both together, and there'll be a control group with no intervention.

What are the potential side effects?

Since this trial involves non-invasive cooling techniques such as fans and water sprays rather than medication or surgery, side effects are minimal but may include discomfort from coldness or skin irritation from prolonged moisture exposure.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within 60 minutes before each simulated heat wave exposure, during each simulated heat wave exposure (up to 3 hours), and within 2 hours after the simulated heat wave exposure

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within 60 minutes before each simulated heat wave exposure, during each simulated heat wave exposure (up to 3 hours), and within 2 hours after the simulated heat wave exposure

This trial's timeline: 3 weeks for screening, Varies for treatment, and within 60 minutes before each simulated heat wave exposure, during each simulated heat wave exposure (up to 3 hours), and within 2 hours after the simulated heat wave exposure for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in core body temperature

Change in left ventricular function

Secondary study objectives

Arterial blood pressure

Cardiac output

Cerebral perfusion

+9 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Very hot and dryExperimental Treatment4 Interventions

Subjects will be exposed to 3 hours in a climate chamber set to approximately 47 deg C and 15% relative humidity, which reflects a very hot and dry heat wave condition similar to the 2018 Los Angeles heat wave. Four visits will be required to complete this arm, with each visit a different cooling modality applied.

Group II: Hot and humidExperimental Treatment4 Interventions

Subjects will be exposed to 3 hours in a climate chamber set to approximately 41 deg C and 40% relative humidity, which reflects hot and humid heat wave similar to the 1995 Chicago heat wave. Four visits will be required to complete this arm, with each visit a different cooling modality applied.

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