Dairy Foods for Insulin Resistance

Recruiting in Palo Alto (17 mi)

+3 other locations

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Midwest Center for Metabolic and Cardiovascular Research

Trial Summary

What is the purpose of this trial?The objectives of this trial are to assess the effects of adding 2 servings/d of either full-fat or low-fat fermented dairy products to the diet, as a replacement for non-dairy foods with macronutrient composition similar to the low-fat fermented dairy condition, on insulin sensitivity, erythrocyte fatty acid profile and other cardiometabolic health markers in metabolically at-risk adults.

Eligibility Criteria

Adults aged 18-74 with a BMI of 25-39.99 and high fasting triglyceride levels who are in good health, can maintain their usual physical activity, avoid vigorous exercise before clinic visits, abstain from alcohol and marijuana use for 24 hours prior to visits, and follow dietary instructions for the study period. Exclusions include recent cancer survivors, those on unstable medication regimens affecting blood pressure or metabolism, extreme dieters or those with certain medical conditions.

Inclusion Criteria

Subject has a rating of 7 to 10 on the Vein Access Scale at screening

Subject has no plans to change smoking habits during the study

Subject has a BMI of 25.00 kg/m2 to 39.99 kg/m2 at screening

+10 more

Exclusion Criteria

My weight has changed by about 10 pounds in the last 3 months.

Subject has a current or recent history, or strong potential, for drug or alcohol abuse

I can understand and follow the study's requirements without any health issues interfering.

+17 more

Participant Groups

The trial is testing the impact of adding two servings per day of either full-fat or low-fat fermented dairy products compared to non-dairy foods on insulin sensitivity and other markers related to heart health and metabolism in adults at risk due to body weight or lipid profiles.

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Full-fat fermented dairyExperimental Treatment1 Intervention

1 serving per day of full-fat yogurt and full-fat fermented cheese

Group II: Low-fat fermented dairyActive Control1 Intervention

1 serving per day of low-fat yogurt and lower-fat fermented cheese (e.g., reduced-fat or low-fat fermented cheese).

Group III: Non-dairy, non-fermented foodsPlacebo Group1 Intervention

2 servings per day of nondairy, nonfermented foods with a macronutrient composition that is similar to that of the low-fat fermented dairy condition.