← Back to Search

AML participants who are receiving or are planned to receive azacitidine plus venetoclax for Acute Myeloid Leukemia

N/A
Waitlist Available
Led By Brittany Ragon, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 3 years
Awards & highlights

Summary

The purpose of this research is to see how certain genetic variations relate to side effects and outcomes experienced while receiving treatment with azacitidine and venetoclax.

Eligible Conditions
  • Acute Myeloid Leukemia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 3 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Toxicity side effect
Secondary study objectives
Disease Response
Dose Modification
Dose modification due to nausea or diarrhea
+3 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: AML participants who are receiving or are planned to receive azacitidine plus venetoclaxExperimental Treatment1 Intervention
Buccal swabs for SNPs and pharmacogenomic analysis will be collected at baseline. Venetoclax peak and trough levels will be obtained during SOC Aza/Ven treatments. CYP3A activity will also be evaluated. Demographic and cancer related history will be acquired for each participant. During study participation, cancer treatment details including administration, dose modifications, delays, and reductions, including specific grade 3 toxicities, stem cell transplant status, symptom burden, disease response, and survival will be collected. Participants will be taken off study after three years.

Find a Location

Who is running the clinical trial?

Swim Across AmericaUNKNOWN
6 Previous Clinical Trials
205 Total Patients Enrolled
Wake Forest University Health SciencesLead Sponsor
1,266 Previous Clinical Trials
1,013,657 Total Patients Enrolled
Atrium Health Levine Cancer InstituteOTHER
24 Previous Clinical Trials
1,789 Total Patients Enrolled
~33 spots leftby Jul 2027
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top