HFNC vs Nasal Cannula in Mild Chronic Obstructive Pulmonary Disease Exacerbation
Recruiting in Palo Alto (17 mi)
Overseen ByQingyuan Zhan, M.D.
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: China-Japan Friendship Hospital
No Placebo Group
Approved in 5 jurisdictions
Trial Summary
What is the purpose of this trial?For AECOPD patients, only 8% patients ventilated by noninvasive and invasive positive pressure ventilation. Nasal cannula is the most common pattern of oxygen therapy in mild AECOPD. As a low flow oxygen therapy, nasal cannula has many disadvantages.Therefore, we design a randomized controlled trial(RCT)to explore whether HFNC would be better than nasal cannula to prevent the aggravation of respiratory failure and endotracheal intubation in mild AECOPD.
Eligibility Criteria
Inclusion Criteria
AECOPD; pH≥7.35, PaCO2>45 mmHg
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: High flow nasal cannulaExperimental Treatment1 Intervention
High flow nasal cannula(OptiflowTM); Flow 25-60 L/min is set according to patients' comfort; FiO2 is adjusted to maintain peripheral capillary oxygen saturation(SpO2) 90-95%; temperature is set at 37.
Group II: Nasal cannulaActive Control1 Intervention
Nasal cannula;set oxygen flow to keep SpO2 90-95%
High flow nasal cannula is already approved in European Union, United States, Canada, Japan, Australia for the following indications:
🇪🇺 Approved in European Union as High flow nasal cannula for:
- Postoperative respiratory support
- Acute respiratory failure
- Obesity-related respiratory failure
🇺🇸 Approved in United States as High flow nasal cannula for:
- Postoperative respiratory support
- Acute respiratory failure
- Obesity-related respiratory failure
🇨🇦 Approved in Canada as High flow nasal cannula for:
- Postoperative respiratory support
- Acute respiratory failure
- Obesity-related respiratory failure
🇯🇵 Approved in Japan as High flow nasal cannula for:
- Postoperative respiratory support
- Acute respiratory failure
- Obesity-related respiratory failure
🇦🇺 Approved in Australia as High flow nasal cannula for:
- Postoperative respiratory support
- Acute respiratory failure
- Obesity-related respiratory failure
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Loading ...
Who Is Running the Clinical Trial?
China-Japan Friendship HospitalLead Sponsor