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Cognitive Behavioral Therapy + Valuation for Depression and Anxiety

N/A
Recruiting
Research Sponsored by Virginia Polytechnic Institute and State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Mood, anxiety, or anhedonia symptoms that affect functioning
Be between 18 and 65 years old
Must not have
History of chemotherapy for cancer
History of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness
Timeline
Screening 3 weeks
Treatment Varies
Follow Up study entrance to exit, an average of 12 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial looks at how different people react to winning or losing, and if these responses are different for people who have depression, anhedonia, or anxiety.

Who is the study for?
This trial is for individuals who can see a computer display, are experiencing mood issues, anxiety, or anhedonia (lack of pleasure) that affect their daily life, speak English fluently, and can play simple computer games. It's not for those with MRI contraindications, seizure disorders, significant head injuries, hormone disorders, recent electroconvulsive therapy or chemotherapy treatments for cancer.
What is being tested?
The study is testing how cognitive behavioral therapy and two types of valuation tasks (with and without instruction) influence the way people perceive rewards and losses. The goal is to understand these processes in those suffering from depressed moods or anxiety.
What are the potential side effects?
Since this trial involves psychological assessments and non-invasive therapies like cognitive behavioral therapy rather than medication or surgical interventions, side effects are minimal but may include temporary emotional discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I experience mood swings, anxiety, or lack of pleasure that impacts my daily life.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had chemotherapy for cancer before.
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I have had seizures, a stroke, or a serious head injury.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~study entrance to exit, an average of 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and study entrance to exit, an average of 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
change in proportion correct on the 'N-arm bandit learning task'
Secondary study objectives
change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)
change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)
change in depression symptoms (Beck Depression Inventory)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Active Control
Group I: Cognitive behavioral therapyActive Control1 Intervention
cognitive behavioral therapy for depression, anxiety, and/or anhedonia
Group II: Valuation with instructionActive Control1 Intervention
repeat laboratory sessions of a reward/loss learning computer game with specific instructions
Group III: Valuation without instructionActive Control1 Intervention
repeat laboratory sessions of a reward/loss learning computer game without specific instructions

Find a Location

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityLead Sponsor
153 Previous Clinical Trials
24,853 Total Patients Enrolled

Media Library

Cognitive Behavioral Therapy Clinical Trial Eligibility Overview. Trial Name: NCT05384158 — N/A
Neurobehavioral Components of Reward and Loss Valuation Research Study Groups: Cognitive behavioral therapy, Valuation with instruction, Valuation without instruction
Neurobehavioral Components of Reward and Loss Valuation Clinical Trial 2023: Cognitive Behavioral Therapy Highlights & Side Effects. Trial Name: NCT05384158 — N/A
Cognitive Behavioral Therapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT05384158 — N/A
~81 spots leftby Jul 2026
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