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Psychological Treatments for Obsessive-Compulsive Disorder

N/A

Recruiting

Led By Adam S Radomsky, PhD

Research Sponsored by Concordia University, Montreal

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of OCD

Be older than 18 years old

Must not have

Participants on medication must be on a stable dose (i.e. have maintained a consistent dose for at least three months) and agree not to change their medication regimen for the duration of the study

Diagnosis of bipolar disorder (I or II)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion (week 3; week 6; one week post therapy; 6 month follow-up; 12 month follow-up).

Awards & highlights

No Placebo-Only Group

Summary

This trial will compare a traditional behavioral approach to OCD with a newer cognitive-based approach to see which is more effective and more acceptable to patients.

Who is the study for?

This trial is for English-speaking individuals diagnosed with OCD who are not currently experiencing psychosis, suicidal thoughts, bipolar disorder, or substance abuse. Participants on medication must have been on a stable dose for at least three months and agree to keep it unchanged during the study.

What is being tested?

The study compares traditional Exposure and Response Prevention (ERP) therapy with a newer cognitive approach for treating OCD. The goal is to see if the cognitive method reduces symptoms as effectively as ERP while being more acceptable and having lower dropout rates.

What are the potential side effects?

While there may not be direct side effects from these psychological treatments, participants might experience increased anxiety or distress initially when facing their fears in ERP or engaging in challenging cognitive exercises.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with OCD.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have been on the same dose of my medication for at least three months and agree not to change it during the study.

Select...

I have been diagnosed with bipolar disorder.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion (week 3; week 6; one week post therapy; 6 month follow-up; 12 month follow-up).

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion (week 3; week 6; one week post therapy; 6 month follow-up; 12 month follow-up).

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion (week 3; week 6; one week post therapy; 6 month follow-up; 12 month follow-up). for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Incidents of participants that drop-out of treatment

Incidents of participants that refuse treatment

Treatment and Acceptability Adherence Scale (TAAS; Milosevic, Levy, Alcolado & Radomsky, 2015)

Secondary study objectives

Anxiety Disorders Interview Schedule for DSM-5 (ADIS-5; Brown & Barlow, 2014)

The Vancouver Obsessional Compulsive Inventory (VOCI; Thordarson, Radomsky, Rachman, et al., 2004)

The Yale-Brown Obsessive Compulsive Scale (YBOCS; Goodman, Price, Rasmussen, et al., 1989)

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive TherapyExperimental Treatment1 Intervention

A modularized, cognitive-behavioural therapy intervention that incorporates evidence gathering and behavioural experiments. Our CT protocols rely heavily on behavioural experiments which are typically targeted and brief exercises designed to permit clients/patients to gather disconfirmatory evidence about their beliefs.

Group II: Behavioural TherapyActive Control1 Intervention

Method of behavioral therapy and form of exposure and response prevention therapy in which individuals confront their fears and discontinue their escape response. Exposures in this protocol are prolonged and repeated, requiring clients/patients to engage in a series of exposures to feared stimuli (e.g., contaminants, doubts, intrusive thoughts), and to refrain from engaging in compulsive behaviour until their anxiety subsides.

0 / 3Eligibility criteria met