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Drug Effects for Postural Orthostatic Tachycardia Syndrome

N/A
Waitlist Available
Led By David Robertson, MD
Research Sponsored by Satish R. Raj
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Orthostatic intolerance
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved
Approved for 5 Other Conditions
No Placebo-Only Group

Summary

This trial is to study the effects of different drugs on people with a syndrome that causes symptoms like a fast heart rate, fatigue, and dizziness when standing up.

Who is the study for?
This trial is for young adults, especially females, who experience rapid heartbeat, fatigue, lightheadedness, and other symptoms when standing up (Orthostatic Intolerance). Participants must be able to give informed consent.
What is being tested?
The study aims to understand the causes of Orthostatic Intolerance by using cardiovascular physiological tests like DAXOR for blood volume measurement, QSweat for sweat production analysis, and checking intrinsic heart rate.
What are the potential side effects?
Since this trial involves diagnostic procedures rather than medications or invasive treatments, side effects are minimal but may include discomfort from testing equipment or minor reactions at sensor attachment sites.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I feel dizzy or faint when standing up.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: PatientsExperimental Treatment3 Interventions
Patients with orthostatic intolerance
Group II: Healthy Control SubjectsExperimental Treatment3 Interventions
Healthy subjects to determine "normal" response
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
QSweat
1996
Completed Phase 1
~10

Find a Location

Who is running the clinical trial?

Satish R. RajLead Sponsor
6 Previous Clinical Trials
430 Total Patients Enrolled
2 Trials studying Postural Orthostatic Tachycardia Syndrome
200 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
National Institutes of Health (NIH)NIH
2,812 Previous Clinical Trials
8,161,211 Total Patients Enrolled
7 Trials studying Postural Orthostatic Tachycardia Syndrome
334 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
David Robertson, MDPrincipal InvestigatorVanderbilt University
3 Previous Clinical Trials
138 Total Patients Enrolled

Media Library

Healthy Control Subjects Clinical Trial Eligibility Overview. Trial Name: NCT00608725 — N/A
Postural Orthostatic Tachycardia Syndrome Research Study Groups: Healthy Control Subjects, Patients
Postural Orthostatic Tachycardia Syndrome Clinical Trial 2023: Healthy Control Subjects Highlights & Side Effects. Trial Name: NCT00608725 — N/A
Healthy Control Subjects 2023 Treatment Timeline for Medical Study. Trial Name: NCT00608725 — N/A
~25 spots leftby Dec 2027
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