Topiramate for Schizophrenia
Trial Summary
What is the purpose of this trial?
Clozapine is the sole AP agent with superiority in treatment refractory schizophrenia, but it also is associated with the greatest risk of weight gain and other metabolic abnormalities. Topiramate, an anticonvulsant agent, possesses a weight-reducing effect. Furthermore, some studies have suggested that Topiramate may be associated with improvements in psychopathology in treatment refractory schizophrenia. Here the investigators propose to determine the role of topiramate for augmentation purposes (psychopathology) and as an adjunctive pharmacological intervention for weight loss in overweight/obese individuals with Ultra-Treatment Resistant Schizophrenia or Schizoaffective disorder taking clozapine.
Research Team
Margaret Hahn, PhD, MD
Principal Investigator
Centre for Addiction and Mental Health
Eligibility Criteria
This trial is for individuals aged 17-59 with schizophrenia or schizoaffective disorder, who are overweight and have been on clozapine treatment. They must not have major organ dysfunction, uncontrolled diabetes, recent major medical events, a history of renal stones or glaucoma, acute suicidal risk, or changes in certain medications recently.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Topiramate (Anticonvulsant)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Centre for Addiction and Mental Health
Lead Sponsor
Dr. Catherine Zahn
Centre for Addiction and Mental Health
Chief Executive Officer since 2009
MD, University of Toronto
Dr. James Graham
Centre for Addiction and Mental Health
Chief Medical Officer since 2024
PhD in Functional Neuroimaging
Ontario Ministry of Health and Long Term Care
Collaborator