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Prostacyclin Analogue

Oral treprostinil for Pulmonary Arterial Hypertension (ADAPT Trial)

N/A
Waitlist Available
Research Sponsored by United Therapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to week 78
Awards & highlights

Summary

This prospective, observational, multicenter, patient registry will follow patients who are receiving treatment with Orenitram for the treatment of PAH for up to 78 weeks from Orenitram initiation

Eligible Conditions
  • Pulmonary Arterial Hypertension

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to week 78
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to week 78 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
To assess treatment-related outcomes during routine clinical care.

Side effects data

From 2020 Phase 2 trial • 12 Patients • NCT02663895
67%
Headache
50%
Abdominal Pain
42%
Diarrhea
25%
Nausea
17%
Jaw Pain
17%
dizziness
17%
Flushing
8%
epistaxis
8%
hypotension
8%
weight loss
100%
80%
60%
40%
20%
0%
Study treatment Arm
Oral Treprostinil

Trial Design

1Treatment groups
Experimental Treatment
Group I: Oral treprostinilExperimental Treatment1 Intervention
Sustained-release oral tablets for three times daily (TID) administration in prostacyclin naive and prostacyclin transition patients
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Treprostinil
FDA approved

Find a Location

Who is running the clinical trial?

United TherapeuticsLead Sponsor
110 Previous Clinical Trials
14,226 Total Patients Enrolled
59 Trials studying Pulmonary Arterial Hypertension
7,985 Patients Enrolled for Pulmonary Arterial Hypertension
~37 spots leftby Sep 2025
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