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Central vs Brachial Blood Pressure Targeting for Chronic Kidney Disease (CENTRAL-CKD Trial)

N/A

Waitlist Available

Led By Remi Goupil, MD MSc

Research Sponsored by Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Over 18 years of age

Be older than 18 years old

Must not have

Unwillingness to change anti-hypertensive medication by the attending Nephrologist or patient

Inability to provide consent due to cognitive impairment

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 months

Awards & highlights

No Placebo-Only Group

Summary

This trial is designed to compare the feasibility and effectiveness of targeting central BP in advanced CKD patients as opposed to brachial cuff BP.

Who is the study for?

This trial is for adults over 18 with advanced chronic kidney disease (CKD stages 4 and 5) who have an eGFR <30 mL/min/1.73m2 and a systolic blood pressure between 120-160 mmHg. It's not for those on more than four blood pressure meds, recently hospitalized for heart issues or falls, or likely to die within six months.

What is being tested?

The CENTRAL-CKD trial tests if targeting central blood pressure rather than the usual arm cuff measurement can better manage high blood pressure in CKD patients. Participants are randomly assigned to one of two groups: one aiming for a central BP target under 130 mmHg, the other sticking to standard brachial BP targets.

What are the potential side effects?

Since this study focuses on measuring techniques rather than new medications, side effects may be related to changes in existing hypertension treatment regimens as directed by doctors but are not directly caused by the intervention itself.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am over 18 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am not willing to change my blood pressure medication.

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I cannot give consent because of cognitive issues.

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My kidney function has worsened significantly in the last month.

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I am currently taking 5 or more medications for high blood pressure.

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I have had a kidney transplant or been on dialysis.

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I do not have any major illness that could lead to death within 6 months.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Difference in aortic stiffness

Feasibility: Achieved BP target rate

Feasibility: Completion rate

+5 more

Secondary study objectives

Quality of life (KDQOL-SF questionnaire)

Other study objectives

Major adverse cardiovascular adverse events (cardiovascular mortality, myocardial infarction, stroke, heart failure requiring hospitalisation, peripheral artery disease requiring revascularisation or amputation)