Effect of Continuous Positive Airway Pressure (CPAP) Versus Auto-titrating Continuous Positive Airway Pressure (APAP) on Resistant Hypertension (HTN) and Arterial Stiffness
Palo Alto (17 mi)Overseen byR John Kimoff, MD, FRCP(C)
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: N/A
Waitlist Available
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
No Placebo Group
Trial Summary
What is the purpose of this trial?The primary objective is to evaluate the relative effectiveness of fixed CPAP in comparison to APAP in reducing arterial blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA).
The secondary objectives are: a) to evaluate the relative effectiveness of fixed CPAP versus APAP in improving arterial stiffness, sleep-disordered breathing, sleep quality, inflammatory markers and glucose regulation; b) to identify specific characteristic of persons who respond to the two CPAP modalities in order to identify which device is better for each subject.
Eligibility Criteria
Treatment Details
2Treatment groups
Active Control
Group I: auto-titratingActive Control1 Intervention
Patients being treated for 6 weeks with auto-titrating continuous airway pressure.
Group II: FixedActive Control1 Intervention
Patients receiving 6 weeks of treatment with fixed continuous positive airway pressure.
Find a clinic near you
Research locations nearbySelect from list below to view details:
Royal Victoria HospitalMontreal, Canada
Montreal General HospitalMontreal, Canada
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Who is running the clinical trial?
McGill University Health Centre/Research Institute of the McGill University Health CentreLead Sponsor
OSR Medical Inc.Industry Sponsor