← Back to Search

MyoCI + Memory Reactivation for Stroke Recovery

N/A
Recruiting
Led By Marc W Slutzky, MD/PhD
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age at enrollment is 21 or older
Severe to moderate motor impairment (FMA-UE of 7-40)
Must not have
Visual impairment (such as hemianopia) preventing full view of screen
Substantial arm pain preventing participation for 90 minutes a day
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline at 6 weeks

Summary

This trial will study the effects of a myoelectric computer interface training combined with targeted memory reactivation during sleep in people who have had a stroke.

Who is the study for?
This trial is for chronic stroke survivors aged 21 or older with severe to moderate arm motor impairment, who had their first stroke at least 6 months ago. Participants must have some voluntary shoulder and elbow movement but can't join if they have ferromagnetic implants, are in other studies, struggle with English due to aphasia, suffer from substantial pain or visual impairments that affect screen viewing, or have received spasticity treatment recently.
What is being tested?
The study tests whether combining myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) during sleep can improve arm function in people who've had a stroke. It looks at the effects of this combination over an extended period.
What are the potential side effects?
The description does not specify side effects; however, typical risks may include discomfort from wearing the MyoCI device or fatigue from the exercises. TMR involves audio cues during sleep which should be minimally invasive.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 21 years old or older.
Select...
I have severe to moderate difficulty moving my arms.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have a visual impairment that prevents me from seeing the entire screen.
Select...
I have severe arm pain that stops me from participating in activities for 90 minutes a day.
Select...
I have received spasticity treatment in the last 3 months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline at 6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline at 6 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Wolf Motor Function Test (WMFT)
Secondary study objectives
Fugl-Meyer Assessment of Upper Extremity (UE) Motor Function
Modified Ashworth Scale
Motor Activity Log (MAL)

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Slow-wave sleep (SWS) only TMRExperimental Treatment1 Intervention
TMR during slow-wave sleep only
Group II: Reduced frequency TMRExperimental Treatment1 Intervention
TMR during only subset of sessions
Group III: All phase TMRExperimental Treatment1 Intervention
TMR during every stage of sleep
Group IV: Sham TMRPlacebo Group1 Intervention
Patients receive no TMR

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,647 Previous Clinical Trials
958,582 Total Patients Enrolled
34 Trials studying Stroke
25,361 Patients Enrolled for Stroke
Marc W Slutzky, MD/PhDPrincipal InvestigatorNorthwestern University

Media Library

MyoCI Clinical Trial Eligibility Overview. Trial Name: NCT04312269 — N/A
MyoCI 2023 Treatment Timeline for Medical Study. Trial Name: NCT04312269 — N/A
Stroke Clinical Trial 2023: MyoCI Highlights & Side Effects. Trial Name: NCT04312269 — N/A
Stroke Research Study Groups: All phase TMR, Sham TMR, Slow-wave sleep (SWS) only TMR, Reduced frequency TMR
~10 spots leftby Aug 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top