Unconscious Neuro-reinforcement for Anxiety Disorders (DecNef Trial)

N/A

Recruiting

Led By Michelle G Craske, PhD

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Individual has normal or corrected to normal hearing

Individual has normal or corrected to normal vision

Must not have

Individual has vision problems (including cataracts, amblyopia, or glaucoma)

Individual is unable to maintain focus or to sit during assessment

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 14 days/6 weeks (measured at pre-treatment, 2 weeks, and 6 weeks)

Awards & highlights

No Placebo-Only Group

Summary

This trial is looking at a new way to reduce fear responses in people with phobias like spiders and snakes. The method uses brain activity to unconsciously change how the brain responds to fear, without

Who is the study for?

This trial is for individuals with phobias or anxiety disorders like PTSD, who are looking for a treatment that doesn't involve consciously facing their fears. Participants should be comfortable undergoing fMRI scans and not have conditions that exclude them from such procedures.

What is being tested?

The study tests an innovative neuro-reinforcement method using decoded fMRI to reduce fear responses without conscious exposure to the feared subject. It aims to provide a less distressing alternative to traditional treatments by working unconsciously.

What are the potential side effects?

Since this is a non-invasive brain imaging technique, side effects may include discomfort during the fMRI procedure or mild headaches post-scan. The unconscious intervention itself does not have direct side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My hearing is normal or corrected to normal.

Select...

My vision is normal or corrected to normal with glasses or contacts.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have vision problems like cataracts, lazy eye, or glaucoma.

Select...

I struggle to stay focused or sit still during assessments.

Select...

I am currently taking medication for my mental health.

Select...

I cannot answer screening questions well.

Select...

I have a history of neurological disease or brain injury.

Select...

I have PTSD, OCD, substance use disorder, major depression, bipolar disorder, psychosis, a neurological condition, or a serious unstable medical condition.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 14 days/6 weeks (measured at pre-treatment, 2 weeks, and 6 weeks)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~14 days/6 weeks (measured at pre-treatment, 2 weeks, and 6 weeks)

This trial's timeline: 3 weeks for screening, Varies for treatment, and 14 days/6 weeks (measured at pre-treatment, 2 weeks, and 6 weeks) for reporting.