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Nexium vs Tums
Introduction
For patients dealing with troublesome symptoms of heartburn, acid reflux or other types of gastroesophageal reflux disease (GERD), certain drugs can provide relief by reducing the amount of acid in your stomach. Nexium and Tums are two such medications often recommended for these conditions. They both serve to decrease acidity within the stomach but do so through different mechanisms. Nexium is known as a proton pump inhibitor (PPI) that works by blocking an enzyme in the wall of the stomach that produces acid. On the other hand, Tums acts more directly as an antacid which neutralizes existing stomach acid on contact rather than affecting its production. While both can offer relief from discomfort, they differ in strength and duration of effect with Nexium being generally stronger and longer lasting.
Nexium vs Tums Side By Side
| Attribute | Nexium | Tums |
|---|---|---|
| Brand Name | Nexium | Tums |
| Contraindications | Should not be taken with certain types of antiretroviral drugs. Can potentially lead to kidney problems or bone fractures if used for extended periods. | Overuse may result in constipation or diarrhea. Should not be used excessively without consulting a healthcare provider. |
| Cost | For a 42-count pack of Nexium (20 mg) averages around $30. Generic versions can range from as low as $9 to approximately $60. | The cost for Tums Ultra Strength (1000mg) is typically about $7 for a bottle containing 72 tablets. Generic calcium carbonate can be found priced from around $3 up to about $15. |
| Generic Name | Esomeprazole | Calcium Carbonate |
| Most Serious Side Effect | Severe kidney problems, signs of low magnesium levels such as fatigue, seizures, dizziness, abnormal or fast heartbeat, jitteriness, jerking movements or shaking (tremors), muscle weakness, spasms (cramps), muscle aches or pains. | Signs of an allergic response, confusion and mood swings, evidence of high calcium levels such as nausea/vomiting, loss of appetite, unusual weight loss, increased thirst/urination, irregular heartbeat or fainting. |
| Severe Drug Interactions | Certain types of antiretroviral drugs. | No specific severe drug interactions mentioned, but always consult with a healthcare provider. |
| Typical Dose | Oral dosages range from 20-40 mg/day, with 20 mg/day being sufficient for treating GERD in most people. | 2 to 4 tablets chewed and swallowed at the onset of discomfort, up to a maximum dosage of 7 times in a 24-hour period for those aged over 12 years old. |
What is Nexium?
Esomeprazole (the generic name for Nexium) is a proton pump inhibitor that significantly reduces stomach acid production, marking a major progression over antacids like calcium carbonate (found in Tums). Esomeprazole was first approved by the FDA in 2001. Nexium works by blocking the final step of gastric acid secretion, effectively trapping less acidity in the stomach for longer periods of time than usual. It is prescribed for conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Unlike Tums which neutralizes existing stomach acid upon ingestion but doesn't prevent further acid production, Nexium has a more focused approach on inhibiting future acidity with little to no influence on immediate relief from heartburn symptoms. This results in it having fewer instant effects but provides more long-term benefits compared to other quick-action treatments like Tums.
What conditions is Nexium approved to treat?
Nexium is approved for the treatment of various conditions related to excess stomach acid:
- Gastroesophageal Reflux Disease (GERD)
- Erosive Esophagitis
- Hypersecretory conditions such as Zollinger-Ellison syndrome
- Prevention of gastric ulcers caused by NSAIDs or infection with Helicobacter pylori when used in combination with antibiotics.
How does Nexium help with these illnesses?
Nexium helps to manage heartburn and other symptoms associated with gastroesophageal reflux disease (GERD) by reducing the amount of acid produced in the stomach. It does this by inhibiting a system in the gastric cells known as proton pump. The proton pump is responsible for secreting hydrochloric acid into the stomach, which contributes to breaking down food but can also lead to painful and damaging conditions when overproduced or regurgitated into esophagus. By blocking this system, Nexium allows any damage that has been done due to acid exposure time to heal and prevents further harm from occurring. On the other hand, Tums work differently; they do not reduce production of stomach acid but instead help neutralize it once it's there providing more immediate relief from heartburn symptoms. However, their effect is temporary and best suited for occasional discomfort rather than chronic conditions.
What is Tums?
Tums is a brand name for an antacid composed of calcium carbonate, which works to neutralize stomach acid. It directly interacts with the gastric acids in your stomach, reducing their acidity and offering relief from heartburn symptoms. This fast-acting process makes Tums particularly useful for immediate relief and it has been trusted by consumers since its first introduction to the market in 1930. Unlike proton pump inhibitors such as Nexium, Tums does not reduce the production of acid over time nor does it require consistent dosing to remain effective. Its side-effect profile is also different than that of PPIs like Nexium; while long-term usage of Nexium can potentially cause kidney damage or osteoporosis, Tums are generally well tolerated even with regular use. The primary side effects may include constipation or kidney stones due to excess calcium but these are rare when taken properly at recommended doses.
What conditions is Tums approved to treat?
Tums is approved for the treatment of conditions such as:
- Heartburn
- Upset stomach associated with these symptoms, including indigestion and nausea
- Acid indigestion caused by consuming certain foods or beverages
How does Tums help with these illnesses?
Tums is an over-the-counter antacid that works by directly neutralizing gastric acid in the stomach, thereby providing immediate relief from heartburn and indigestion. It functions as a source of calcium, but its primary benefit is to quickly decrease stomach acidity through its alkaline properties. Tums differs significantly from Nexium; while Nexium acts as a proton pump inhibitor (PPI) reducing the production of acid by blocking the enzyme in the wall of the stomach that produces it, Tums operates at a symptom level rather than addressing any underlying causes. Therefore, Tums may be suggested for those who experience occasional heartburn or indigestion whereas Nexium might be recommended for patients with recurring issues since it has more prolonged effects on inhibiting acid production.
How effective are both Nexium and Tums?
Both esomeprazole (Nexium) and calcium carbonate (Tums) are widely used over-the-counter drugs for managing symptoms associated with acid reflux, heartburn, and other stomach-acidity related conditions. While both have a similar goal - to reduce the acidity in the stomach – their methods of doing so differ significantly.
Esomeprazole is a proton pump inhibitor that works by decreasing the amount of acid produced in the stomach, providing longer-lasting relief from heartburn and acid reflux symptoms than antacids like Tums. Studies have shown esomeprazole to be superior at healing erosive esophagitis caused by chronic gastroesophageal reflux disease (GERD), due to its ability to significantly decrease gastric acidity. However, it may take one-to-four days before full effect is seen.
On the other hand, Tums work as an antacid by neutralizing existing stomach acid on contact which provides faster but shorter-term relief compared to Nexium. They also provide supplemental calcium which can be beneficial for those needing additional dietary intake of this mineral.
In terms of safety profiles, both medications are generally well-tolerated. Esomeprazole may cause side effects such as headache or diarrhea while long term use has been linked with vitamin B12 deficiency and increased risk for bone fracture among other concerns. Meanwhile, excessive use of Tums can lead to problems such as constipation or even kidney stones due mainly to their high content of elemental calcium.
Overall choice between these two medications should depend largely on individual needs including severity and frequency of symptoms along with personal medical history that could influence tolerability.
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At what dose is Nexium typically prescribed?
Oral dosages of Nexium range from 20-40 mg/day, but studies have indicated that 20 mg/day is sufficient for treating gastroesophageal reflux disease (GERD) in most people. Children and adolescents may be started on 10 mg/day. In either population, dosage can be increased after a few weeks if there is no response. The maximum dosage that should not be exceeded in any case is 40 mg/day. On the other hand, Tums can be taken at the onset of symptoms at a rate of 2-4 tablets every hour as symptoms persist or as directed by your healthcare provider. Do not exceed more than seven doses in a 24-hour period unless advised otherwise by your doctor.
At what dose is Tums typically prescribed?
Tums can be taken for immediate relief of heartburn and acid indigestion symptoms. The initial dose is typically 2 to 4 tablets, chewed and swallowed, at the onset of discomfort. If needed, additional doses may be taken up to a maximum dosage of 7 times in a 24-hour period for those aged over 12 years old or under medical supervision. For children under twelve years old, use should only be upon the advice of a doctor. Tums offers prompt symptom relief but does not have long-lasting effects like Nexium; thus if symptoms persist beyond two weeks while using Tums, it's recommended to consult with your healthcare provider.
What are the most common side effects for Nexium?
Some common side effects of Nexium include:
- Headache
- Diarrhea, nausea, constipation, or dry mouth
- Gas (flatulence)
- Stomach pain
- Drowsiness or dizziness
- Swelling in your hands or feet
On the other hand, Tums is generally well-tolerated but possible side effects can include:
- Constipation
- Flatulence
- High calcium levels (hypercalcemia)
Are there any potential serious side effects for Nexium?
While both Nexium and Tums are used for the relief of heartburn, they can have different side effects. Here are some potential severe side effects that you should be aware of while taking Nexium:
- An allergic reaction like rash, itching or hives on the skin; swelling of the face, lips, tongue or other parts of body; shortness of breath, wheezing or trouble breathing
- Reddening of the skin with blisters or peeling and possibly accompanied by fever
- Signs indicative of low magnesium levels in your body such as fatigue; seizures; dizziness; abnormal or fast heartbeat; jitteriness, jerking movements or shaking (tremors); muscle weakness, spasms (cramps), muscle aches or pains
- Blurred vision and difficulty seeing clearly.
- Rapid weight gain along with increased urination.
In extremely rare cases people have reported experiencing severe kidney problems which may include pain in your stomach area (abdomen) associated with blood in urine.
If you experience any such symptoms while taking Nexium then seek immediate medical attention. On comparison to Tums these side effects are quite rare but it is important to be vigilant about any changes observed when starting new medication.
What are the most common side effects for Tums?
Tums can have the following side effects:
- Dry mouth
- Constipation or diarrhea
- Stomach pain if taken in large doses
- Nausea, possibly leading to vomiting
- Increased thirst and more frequent urination due to high calcium levels from excessive intake.
It's important to note that while Tums are generally well-tolerated, they should be used as directed. Excessive use can lead to imbalances of minerals in your body such as calcium and phosphorus. If you experience severe or prolonged symptoms while taking Tums, it is advisable to consult with your healthcare provider.
Are there any potential serious side effects for Tums?
While Tums is generally well-tolerated, it can occasionally lead to adverse reactions. The following symptoms may indicate a serious reaction to Tums:
- Signs of an allergic response: hives, itching, difficulty breathing or swallowing; swelling of the face, lips, tongue or throat
- Confusion and mood swings
- Evidence of high calcium levels such as nausea/vomiting, loss of appetite, unusual weight loss
- Increased thirst/urination
- Irregular heartbeat or fainting.
If you experience any of these issues while taking Tums for heartburn relief or calcium supplementation, discontinue use and seek immediate medical attention.
Contraindications for Nexium and Tums?
Both Nexium and Tums, like most other medications designed to combat heartburn and acid reflux, may cause side effects or worsen certain conditions. If you notice your symptoms persisting or worsening despite taking these medications, please seek immediate medical attention.
Neither Nexium nor Tums should be taken if you are using certain types of antiretroviral drugs. Always inform your healthcare provider about all the medicines that you are currently taking; some drugs will require a specific period to clear from the system in order to prevent dangerous interactions with both Nexium and Tums.
Nexium is known as a proton pump inhibitor (PPI) and can potentially lead to kidney problems or bone fractures if used for extended periods. On the other hand, overuse of antacids such as Tums may result in constipation or diarrhea.
It's important to remember that while Tums work by neutralizing stomach acid on contact, Nexium works by reducing the actual production of stomach acid hence providing longer relief but takes longer time before effects kick-in.
How much do Nexium and Tums cost?
For the brand name versions of these drugs:
- The price for a 42-count pack of Nexium (20 mg) averages around $30, which works out to roughly $0.70 per day.
- The cost for Tums Ultra Strength (1000mg), on the other hand, is typically about $7 for a bottle containing 72 tablets. If you're taking an average dosage of two tablets per day, that's less than $0.10/day.
Thus, if your symptoms are manageable with Tums and you don't need the extra strength provided by Nexium, then it would be more economical to choose Tums on a daily basis. However, cost should not be your primary factor in determining which medication is right for you.
For the generic versions of Nexium (esomeprazole) and Tums (calcium carbonate), costs can be significantly lower:
- Esomeprazole is available in packs from 14 up to 90 capsules with prices ranging from as low as $9 ($0.64/day) to approximately $60 ($0.67/day).
- Calcium carbonate can generally be found in bottles between 60 and 500 count priced from around $3 ($0.05/day) up to about $15 ($0.03–$0.25/day). Again this depends heavily on dosage needs.
Popularity of Nexium and Tums
Esomeprazole, in generic form as well as brand names like Nexium, was estimated to have been prescribed to about 16.9 million people in the US in 2020. Esomeprazole accounted for approximately 20% of proton pump inhibitor (PPI) prescriptions and around 8% of all gastric acid reduction drugs in the US. It appears to be one of the most common PPIs used, alongside omeprazole and pantoprazole. The prevalence of esomeprazole has seen a steady increase since its introduction in early 2001.
Calcium carbonate antacids such as Tums have remained popular over-the-counter choices for quick relief from occasional heartburn or indigestion symptoms throughout this period despite not being prescription medications. While exact numbers are harder to determine due to their non-prescription status, it's safe to say they are widely used across the nation thanks to their immediate effect on neutralizing stomach acid compared with PPIs' longer-term inhibition mechanism.
Conclusion
Both Nexium (esomeprazole) and Tums (calcium carbonate) are commonly used for the treatment of acid reflux symptoms. They work through different mechanisms, with Nexium being a proton pump inhibitor that reduces stomach acid production, while Tums is an antacid that neutralizes existing stomach acid.
Nexium is often considered as a first-line treatment option for severe or chronic cases due to its potency in suppressing gastric acid secretion over a prolonged period. It may require prescription depending on the dose and duration of therapy advised by your physician. Meanwhile, Tums can be helpful for immediate relief from heartburn or indigestion and is available over-the-counter without a prescription.
While both drugs are available in generic form offering cost savings, it's important to note that they have different usage instructions and potential side effects; Nexium might cause headache, diarrhea, nausea among others while excessive use of Tums may lead to constipation or kidney stones due to its calcium content. Patients should consult their healthcare provider if they notice any worsening symptoms or side effects upon using these medications.
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Refrences
- McKeage, K., Blick, S. K. A., Croxtall, J. D., Lyseng-Williamson, K. A., & Keating, G. M. (2008). Esomeprazole. Drugs. Springer Science and Business Media LLC.http://doi.org/10.2165/00003495-200868110-00009
- Beck, J. (2004, March). Efficacy of Esomeprazole in Patients With Acid-Peptic Disorders. Gastroenterology Nursing. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1097/00001610-200403000-00002
- Park, S. H., Lee, K. N., Lee, O. Y., Choi, M. G., Kim, J.-H., Sung, I.-K., … Jeon, Y. C. (2022, June 22). A Randomized, Double-Blind, Active-Control, Noninferiority, Multicenter, Phase 4 Study to Evaluate the Efficacy and Safety of Esomeprazole/Sodium Bicarbonate 20/800 mg in Patients with Nonerosive Gastroesophageal Reflux Disease. Gut and Liver. The Editorial Office of Gut and Liver.http://doi.org/10.5009/gnl220023