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Renova vs Tazorac
Introduction
For patients struggling with acne or skin aging, certain topical creams that adjust the structure and function of the epidermal cells can help in rejuvenating aged skin and managing acne symptoms. Renova and Tazorac are two such drugs that are prescribed for these conditions. They each impact different aspects of skin cell behavior but both have effects in improving the appearance and health of your skin. Renova is a form of vitamin A, it helps to increase the turnover rate of cells thus promoting clear skin by reducing fine wrinkles, mottled light spots, and making rough facial skin feel smoother. On the other hand, Tazorac belongs to a class known as retinoids (also derived from Vitamin A) and works by affecting growth of skin cells; it not only assists with psoriasis plaques but also aids in treating acne by allowing natural exfoliation to unclog pores.
Renova vs Tazorac Side By Side
| Attribute | Renova | Tazorac |
|---|---|---|
| Brand Name | Renova | Tazorac |
| Contraindications | Pregnancy, planning to become pregnant, use of fluoroquinolone antibiotics, exposure to sunlight or artificial UV rays | Pregnancy, planning to become pregnant, use of fluoroquinolone antibiotics, exposure to sunlight or artificial UV rays |
| Cost | Brand name: around $140 for a 40g tube (0.02%). Generic: $30 - $80 for a 20g tube (0.025%) | Brand name: about $400 for a 30g tube (0.1%). Generic: $100 - several hundred dollars for a 15g tube (0.10%) |
| Generic Name | Tretinoin | Tazarotene |
| Most Serious Side Effect | Severe skin reaction: redness, burning sensation, peeling or blistering of the skin | Swelling of face, lips or tongue indicating a possible severe allergic reaction |
| Severe Drug Interactions | Fluoroquinolone antibiotics | Fluoroquinolone antibiotics |
| Typical Dose | 0.02% concentration, applied once daily before bedtime; may increase to 0.05% if necessary | 0.05% cream or gel, applied once daily in the evening; may increase to 0.1% if no improvement |
What is Renova?
Tretinoin (the generic name for Renova) was one of the first retinoids, a class of medications used primarily to treat acne and skin aging. Tretinoin received its first FDA approval in 1971. Renova works by affecting the growth of skin cells and promoting their rapid turnover, effectively "rejuvenating" the outer layer of the skin over time. It is prescribed mainly for treating acne and reducing fine lines and wrinkles. Renova exerts its effects specifically on epidermal keratinocytes with only minor influence on dermal fibroblasts, which results in it having fewer side effects than other retinoids that have stronger effects on these deeper layers of skin.
On the other hand, Tazarotene (the generic name for Tazorac), belongs to a newer generation of retinoids known as acetylenic retinoid drugs approved by FDA later in 1997. They are also used predominantly for treating psoriasis, acne, as well as sun damaged skin. Like tretinoin they affect cell proliferation but seem to be more selective targeting specific genes involved in inflammation making them potentially more effective but possibly associated with higher incidence side-effects compared to older generations like tretionoin or isotrention.
What conditions is Renova approved to treat?
Renova is approved for the treatment of various skin conditions, including:
- Fine facial wrinkles
- Tactile roughness of facial skin
- Hyperpigmentation as a result of chronic sun exposure
Tazorac on the other hand, is used in treating:
- Plaque psoriasis
- Facial acne vulgaris
How does Renova help with these illnesses?
Renova works to improve skin appearance by promoting the turnover of cells in the epidermis, or outermost layer of the skin. It achieves this by increasing production of collagen and reducing keratinocyte cohesion, encouraging dead skin cells to slough off and new, healthier ones to replace them. Collagen is a protein that gives structure and elasticity to your skin while keratinocytes are cells that produce keratin, a key structural material making up hair, nails, and the surface layer of skin. Therefore by stimulating collagen production and decreasing cell adhesion within the stratum corneum (the top layer), Renova can reduce fine lines, wrinkles and improve overall texture.
On the other hand, Tazorac is a retinoid medication designed for both acne treatment and reducing visible signs of aging like fine lines. It functions by modulating gene expression which helps normalize follicle cell growth - preventing formation of comedones (clogged pores). In relation to aging symptoms it also enhances dermal collagen levels just as Renova does but with added benefit in managing acne prone skins due its potent effect on unclogging pores.
What is Tazorac?
Tazorac is a brand name for tazarotene, a retinoid prodrug that converts to its active form within the skin after topical application. It works by binding to nuclear retinoic acid receptors and modifying gene expression, which helps normalize cell growth and differentiation. Tazarotene was first approved by the FDA in 1997. As it's not an alpha-hydroxy acid (AHA) like Renova's main ingredient tretinoin, it doesn't work by exfoliating dead skin cells from the surface of the skin. Its different mechanism of action means that its side-effect profile differs from AHAs - in particular, it might cause less irritation and redness (common side effects with AHAs such as Renova). The impact on cell growth can be advantageous for treating conditions such as psoriasis and acne vulgaris, especially for patients who don't respond well to "typical" AHA treatments such as Renova.
What conditions is Tazorac approved to treat?
Tazorac is a medication that has been approved by the FDA for treating:
- Plaque psoriasis, which appears as raised, red patches covered with a silvery white buildup of dead skin cells or scale.
- Acne Vulgaris, a long-term skin condition characterized by areas of blackheads, whiteheads, pimples and greasy skin.
How does Tazorac help with these illnesses?
Tazorac, like Renova, is a topical medication predominantly used to treat skin conditions such as psoriasis and acne. Tazorac works by affecting the growth of skin cells in the body. It slows down excessive cell reproduction which is typically seen in psoriasis patients while also preventing the hardening of the skin surface – a key characteristic of acne development. Tazorac's action on retinoid receptors may play an essential role in its effectiveness against these common skin disorders. Since it does not significantly affect vitamin A levels directly (like Retinoids), it can be prescribed when a patient doesn't respond well to typical retinoid treatments (such as Renova) or may be combined with them for enhanced results.
How effective are both Renova and Tazorac?
Both tretinoin (Renova) and tazarotene (Tazorac) are reputable in the skincare field for treating acne and aging-related skin conditions, with both medications having been approved by the FDA within a year of each other. Since they function through different means - Renova being a retinoid that targets cell turnover and Tazorac being an acetylenic class retinoid that regulates gene activity - their prescription can be situational.
The efficacy of both drugs in managing symptoms associated with psoriasis was evaluated in double-blind clinical trials conducted in 1997; they exhibited similar success rates as well as comparable safety profiles. The metrics used to measure effectiveness in treating psoriasis did not significantly differ between patients using Tazorac versus those using Renova.
A review conducted on various meta-analysis reports on Renova demonstrated its effectiveness starting from the first week of treatment, favorably over many other topical treatments for fine facial wrinkles, mottled hyperpigmentation, and skin roughness. It is also generally well-tolerated across diverse populations including seniors. This study also highlighted that Renova has become one of the most widely prescribed topical treatments worldwide due to its long-standing reputation.
A 2010 review indicated that Tazorac appears more effective than placebo creams at reducing plaque height or thickness among patients suffering from mild-to-moderate chronic plaque psoriasis but it's typically considered third- or fourth-line option meaning it is commonly considered only after initial therapies have proven ineffective. Substantial research into its use involves co-prescribing alongside another medication so data confirming standalone efficiencies isn't as robust compared to Renova's data. Yet due to unique pharmacology Tazorac may be optimal for patients who didn't respond well initially or need certain side-effects avoided such as local irritation.
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At what dose is Renova typically prescribed?
Topical usage of Renova typically starts with a 0.02% concentration, applied once daily before bedtime to the areas of skin affected by wrinkles or sun damage. However, if this does not produce sufficient results after several weeks, your doctor may increase the concentration to 0.05%. For adolescents and adults alike, it is important to apply only a pea-sized amount for the entire face. Tazorac, on the other hand, begins at a 0.05% concentration and can be increased up to 0.1% if necessary after several weeks of no response - again as per doctor's instructions. Whether you're an adult or adolescent user considering either medication, remember that more is not necessarily better; using too much can lead to increased side effects without improving efficacy.
At what dose is Tazorac typically prescribed?
Tazorac treatment for acne is typically initiated with a small amount of the 0.05% cream or gel, applied once daily in the evening to clean, dry skin. The dose can then be increased to the 0.1% formulation if there's no improvement after several weeks. It should only be used on affected areas and care must be taken not to apply it on healthy skin due to its potency. Always remember that more isn't necessarily better when it comes to potent topical retinoids like Tazorac; using more than directed won't clear up your skin faster, but it may increase the risk of side effects such as dryness, redness and irritation.
What are the most common side effects for Renova?
Common side effects associated with Renova can include:
- Skin redness
- Warmth or stinging immediately after application of the medication
- Skin peeling, dry skin, burning, stinging, itching and tingling
- Sensitivity to sunlight
- Changes in color of treated skin
On the other hand, Tazorac may cause these common side effects:
- Itching
- Redness
- Irritation and a burning sensation at the site of application
- Dry and scaly skin -Painful skin irritation.
It's important to note that these are not all inclusive lists; if you experience any severe reactions while using either product such as hives or difficulty breathing contact your doctor immediately.
Are there any potential serious side effects for Renova?
While using Renova or Tazorac, if you experience any severe reactions it's important to seek medical attention immediately. These may include:
- An allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
- A severe skin reaction: redness, burning sensation, peeling or blistering of the skin.
- Sensitivity to light and sunburns: increased vulnerability to sunlight and UV rays leading to quick sunburns
- Unusual changes in color of treated skin
- Severe dryness and itching on the area where either medication is applied
- Eye irritation: blurred vision due to accidental contact with eyes.
It’s crucial that you monitor any possible side effects while on these treatments. If you experience any significant discomfort or observe worsening conditions despite regular use under prescribed guidelines, consult your healthcare provider promptly.
What are the most common side effects for Tazorac?
Tazorac, like Renova, is a topical medication used for skin conditions such as acne and psoriasis. When using Tazorac, you may notice:
- Dryness or redness of the treated areas
- Peeling or flaking skin
- Burning or stinging sensation upon application
- Itching at the site of application
- Increased sensitivity to sunlight leading to sunburn
- Unusual changes in skin color (either lighter or darker) In rare instances, Tazorac can also result in:
- Swelling of face/lips/eyelids/tongue/throat Always remember that while these side effects could occur they do not happen with everyone. If any of these become particularly bothersome or if you experience anything severe like difficulty breathing after use - contact your healthcare provider immediately.
Are there any potential serious side effects for Tazorac?
Tazorac, like any medication, can potentially lead to adverse side effects. While most people don't experience serious issues, be aware of the following potential reactions:
- An intense burning or stinging sensation on the skin after applying Tazorac
- Redness or peeling of your skin
- A sudden increase in acne sores
- Unusual changes in skin color (either lighter or darker)
- Extreme dryness and irritation of eyes, nose and mouth
- Swelling of face, lips or tongue indicating a possible severe allergic reaction.
If you notice any such symptoms while using Tazorac, it is crucial to immediately consult with your healthcare provider. Much like other medications, what works well for one individual may not suit another; hence personal monitoring and professional advice are key.
Contraindications for Renova and Tazorac?
Both Renova and Tazorac, similar to other topical retinoids, may cause a worsening of skin irritation in some people. If you notice your skin condition deteriorating or an increase in redness, burning sensation or scaling after application of these creams, seek immediate medical attention.
Neither Renova nor Tazorac should be used if you are taking certain antibiotics known as fluoroquinolones. Always inform your physician about any medications you are currently using; fluoroquinolones can make your skin more sensitive to the sun and combined with retinoid use could lead to severe sunburns.
In addition, both Renova and Tazorac products must not be used by women who are pregnant or planning on becoming pregnant due to the risk of birth defects. It is crucial that effective contraception is employed while using these treatments. Also avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds) when using either product as they can heighten your sensitivity leading to sunburn.
How much do Renova and Tazorac cost?
For the brand name versions of these drugs:
- The price of a 40g tube of Renova (0.02%) averages around $140, which works out to approximately $3.50/day if you use 1g per day.
- The price for a 30g tube of Tazorac (0.1%) is about $400, working out to roughly $13.33/day at a usage rate of 1g daily.
Thus, if you are using similar dosage amounts and frequencies for both medications, then brand-name Renova is less expensive on a per-day treatment basis than Tazorac. Please note that cost should not be your primary consideration in deciding which drug suits your needs best.
In terms of generic equivalents for Renova (tretinoin) and Tazorac (tazarotene), costs can be significantly lower:
- Generic tretinoin cream (0.025%, 20 g) is available with prices ranging from around $30 - $80 depending on the location or pharmacy; this translates into an approximate daily cost range from as low as $1.50 up to about $4 when applying a gram each day.
- Likewise, generic tazarotene cream (0.10%, 15 g) can vary widely in price from around $100 - over several hundred dollars based upon location and store pricing; this means potential daily costs anywhere between approximately %6.67 upwards depending on usage rates and specific pricing details at time of purchase.
Popularity of Renova and Tazorac
Tretinoin, in generic form as well as brand names such as Renova, was estimated to have been prescribed to about 1.4 million people in the US in 2020. Tretinoin accounted for just over 15% of retinoid prescriptions in the US. However, it appears to be a commonly used medication for skin rejuvenation and acne treatment.
Tazarotene, including brand versions such as Tazorac, was prescribed to approximately 800 thousand people in the USA in 2020. In the US, Tazorac accounts for about 10% of overall retinoid prescriptions. While effective for both acne and psoriasis treatment due its receptor selectivity, it's less frequently chosen possibly due to potentially higher irritation compared with other topical retinoids like tretinoin or adapalene.
Conclusion
Both Renova (tretinoin) and Tazorac (tazarotene) have extensive records of usage in patients with skin conditions such as acne and psoriasis, backed by numerous clinical studies indicating that they are more effective than placebo treatments. Both drugs work by promoting the turnover of skin cells but through different mechanisms; Renova increases the speed at which surface skin cells are replaced, while Tazorac modulates genes involved in skin cell growth.
Renova is often a first-line treatment option for acne and fine wrinkles due to its proven efficacy over many years. On the other hand, Tazorac may be considered for patients who did not respond well to initial treatments or need a potent topical medication for severe plaque psoriasis or facial acne.
Both medications are available in generic form, offering significant cost savings especially for those paying out-of-pocket. An adjustment period may be required when starting either drug; improvements might not be noticeable right away as it takes time for new healthy skin cells to appear.
The side effect profile is similar between both drugs including dryness, redness, itching or burning sensation on application site. However, there's a higher incidence of these effects with Tazorac due to its potency. It's crucial that patients using either product protect their treated areas from sun exposure since these medications can make your skin more sensitive to sunlight.
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Refrences
- Lebwohl, M., Ast, E., Callen, J. P., Cullen, S. I., Hong, S. R., Kulp-Shorten, C. L., … Chandraratna, R. A. S. (1998, May). Once-daily tazarotene gel versus twice-daily fluocinonide cream in the treatment of plaque psoriasis. Journal of the American Academy of Dermatology. Elsevier BV.http://doi.org/10.1016/s0190-9622(98)70594-8
- Roeder, A., Schaller, M., Schäfer-Korting, M., & Korting, H. C. (2004). Tazarotene: Therapeutic Strategies in the Treatment of Psoriasis, Acne and Photoaging. Skin Pharmacology and Physiology. S. Karger AG.http://doi.org/10.1159/000077236