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What is Amoxapine
AmoxapineThe Generic name of this drug
Treatment SummaryAmoxapine is a type of antidepressant called a tricyclic antidepressant (TCA). It is related to the antipsychotic drug loxapine and works to increase serotonin and norepinephrine levels in the brain. This can help improve mood in people with depression. Amoxapine is used to treat depression, anxiety, and mixed symptoms of depression and anxiety. Common side effects of TCAs include sedation, low blood pressure, blurred vision, dry mouth, constipation, and urinary retention.
Amoxapineis the brand name
Amoxapine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Amoxapine
Amoxapine
1992
5
Effectiveness
How Amoxapine Affects PatientsAmoxapine is a type of antidepressant that is known to have a calming effect. It works differently than other antidepressants and has been shown to reduce the uptake of certain chemicals in the brain (nor-epinephirine and serotonin) and block the response of dopamine receptors to dopamine. It does not work as a monoamine oxidase inhibitor. Clinical studies have shown that amoxapine starts working faster than other antidepressants, such as amitriptyline and imipramine.
How Amoxapine works in the bodyAmoxapine works by preventing the body from reabsorbing the chemical messengers norepinephrine and serotonin.
When to interrupt dosage
The suggested dosage of Amoxapine is subject to the determined illness, for instance Neurotic depression, Psychotic Depression and Agitation. The amount of dosage depends on the method of delivery (e.g. Oral or Tablet) featured in the table beneath.Condition
Dosage
Administration
Depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Generalized Anxiety Disorder
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Agitation
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Mental Depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Psychotic Depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Mental Depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Neurotic depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Amoxapine ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Amoxapine Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Amoxapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Amoxapine is combined with Aclidinium.
Alfuzosin
Major
Amoxapine may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Amoxapine may increase the antipsychotic activities of Amisulpride.
Aripiprazole
Major
Amoxapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Amoxapine Toxicity & Overdose RiskTaking too much amoxapine can have serious side effects, such as seizures, coma, abnormal acid levels in the body, and kidney failure. Seizures are the most common symptom, and can lead to a medical emergency called status epilepticus. In rare cases, kidney failure can develop a couple days after overdosing.
Amoxapine Novel Uses: Which Conditions Have a Clinical Trial Featuring Amoxapine?
819 active clinical trials are investigating the potential of Amoxapine in treating Neurotic Depression, Agitation and Mental Despondency.Condition
Clinical Trials
Trial Phases
Psychotic Depression
0 Actively Recruiting
Generalized Anxiety Disorder
213 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 3
Mental Depression
0 Actively Recruiting
Mental Depression
0 Actively Recruiting
Neurotic depression
0 Actively Recruiting
Depression
330 Actively Recruiting
Phase 1, Phase 2, Early Phase 1, Not Applicable, Phase 4, Phase 3
Agitation
5 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Amoxapine Reviews: What are patients saying about Amoxapine?
5Patient Review
9/13/2020 This drug was more effective than similar treatments I've tried in the past. At first, I experienced periods of involuntary yawning, but I quickly got used to it. My concentration while on this medication was amazing.
5Patient Review
12/8/20085Patient Review
8/3/2011 Amoxapine has been a complete game-changer for me since I started taking it in 1981.
Patient Q&A Section about amoxapine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the brand name for amoxapine?
"Amoxapine is a tricyclic antidepressant that is used to treat symptoms associated with depression, anxiety, or agitation."
Answered by AI
What is amoxapine used to treat?
"This medicine is used to treat the symptoms of depression by increasing levels of certain chemicals in the brain. This medicine is a tricyclic antidepressant (TCA) and is available only with a doctor's prescription."
Answered by AI
Is amoxapine an antipsychotic?
"The drug Amoxapine is marketed as an antidepressant, though it has similar in-vitro profiles, receptor occupancies, and preclinical effects to atypical antipsychotics. Amoxapine has shown to be effective as an atypical antipsychotic in open trials."
Answered by AI
What are the side effects of amoxapine?
"popular antidepressants can cause a number of
side effects, including nausea, drowsiness, weakness or tiredness, nightmares, dry mouth, skin more sensitive to sunlight than usual, changes in appetite or weight, and constipation."
Answered by AI