Clozaril

Schizophrenia, Advance Directives, Parkinson Disease + 6 more
Treatment
10 FDA approvals
20 Active Studies for Clozaril

What is Clozaril

ClozapineThe Generic name of this drug
Treatment SummaryClozapine is a medication used to treat certain mental health disorders. It works by blocking serotonin and dopamine receptors in the brain, reducing the symptoms of psychosis. Clozapine is classified as an atypical antipsychotic agent and is known to cause a rare side effect called agranulocytosis. It is important to monitor blood levels while taking Clozapine to ensure it is taken safely.
Clozarilis the brand name
image of different drug pills on a surface
Clozaril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clozaril
Clozapine
1989
97

Approved as Treatment by the FDA

Clozapine, also called Clozaril, is approved by the FDA for 10 uses which include Schizophrenia, Treatment-Resistant and Schizoaffective Disorders .
Schizophrenia, Treatment-Resistant
Helps manage Treatment Resistant Schizophrenia
Schizoaffective Disorders
Helps manage Schizoaffective Disorders
Suicidal Behaviour
Helps manage Suicidal Behaviour
Treatment Resistant Schizophrenia
Helps manage Treatment Resistant Schizophrenia
Severe Mental Illness
Helps manage Severe Mental Illness
Disease
Helps manage inadequate response to conventional therapy
Schizoaffective Disorder
Helps manage Schizoaffective Disorders
Schizophrenia
Helps manage Schizophrenia
High Risk
Helps manage High Risk
Suicide
Helps manage Suicidal Behaviour

Effectiveness

How Clozaril Affects PatientsClozapine is a medication used to treat schizophrenia, and works by targeting serotonin, dopamine, adrenaline, and histamine receptors in the brain. It can cause side effects such as drowsiness, low blood pressure, and dry mouth. It also carries a risk of serious reactions, such as agranulocytosis (low white blood cell count) or myocarditis (inflammation of the heart muscle). Your doctor will monitor your white blood cell count and other lab values closely while taking this medication, and will also check for signs of myocarditis. If you experience any of these reactions, you should stop taking cl
How Clozaril works in the bodyClozapine works to treat psychosis by blocking certain receptors in the brain. It blocks dopamine receptors to reduce positive symptoms, and serotonin receptors to reduce negative symptoms.

When to interrupt dosage

The advised dosage of Clozaril is contingent upon the specified condition, including High Risk, Severe Mental Illness and Schizoaffective Disorder. The quantity of dosage fluctuates depending on the technique of administration as detailed in the table hereunder.
Condition
Dosage
Administration
Severe Mental Illness
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Parkinson Disease
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Schizophrenia
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Advance Directives
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Schizoaffective Disorder
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
High Risk
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Suicide
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Disease
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Schizophrenia, Treatment-Resistant
, 25.0 mg, 100.0 mg, 50.0 mg, 200.0 mg, 12.5 mg, 150.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral

Warnings

There are 20 known major drug interactions with Clozaril.
Common Clozaril Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Clozapine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Clozapine.
Acepromazine
Major
Clozapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Clozapine is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Clozapine.
Clozaril Toxicity & Overdose RiskClozapine has a serious warning due to its potential to cause a severe decrease in white blood cells.
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Clozaril Novel Uses: Which Conditions Have a Clinical Trial Featuring Clozaril?

230 active clinical trials are currently in progress to analyze the therapeutic potential of Clozaril in High Risk, Parkinsonian Syndromes and Suicide prevention.
Condition
Clinical Trials
Trial Phases
Schizophrenia
97 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2
Schizoaffective Disorder
43 Actively Recruiting
Phase 4, Phase 1, Phase 2, Not Applicable, Phase 3
Schizophrenia, Treatment-Resistant
4 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Suicide
5 Actively Recruiting
Not Applicable
Advance Directives
0 Actively Recruiting
High Risk
0 Actively Recruiting
Disease
0 Actively Recruiting
Parkinson Disease
0 Actively Recruiting
Severe Mental Illness
0 Actively Recruiting

Clozaril Reviews: What are patients saying about Clozaril?

5Patient Review
4/9/2012
Clozaril for Bipolar Disorder in Remission
Clozaril has been a life-saver for me. I've tried many other drugs with varying degrees of success, but the side effects were always too severe. With Clozaril, I finally found a medication that is effective without being overly debilitating.
5Patient Review
6/2/2009
Clozaril for Treatment-Resistant Schizophrenia
Weight gain was a bit extreme, but this drug really helped with my insomnia. I have to go for monthly bloodwork and appointments with the doctor, but it's worth it. The pain in my joints and muscles wasn't severe.
5Patient Review
10/19/2016
Clozaril for Schizophrenia
My brother has been on Clozaril for 12 years plus. He has been in and out of hospitals his whole life and this drug has enabled him to lead somewhat of a normal life. Now, we are unable to find a doctor who takes Medicare and will prescribe this medication. It has been devastating for our family.
5Patient Review
4/28/2017
Clozaril for Schizophrenia
This drug has helped my son immensely. He's been taking it for around a year to manage his schizophrenia and bipolarity, and we've seen vast improvements. His other medications have since been discontinued or decreased in dosage because of this drug, and he's doing great!
5Patient Review
1/14/2013
Clozaril for Suicidal Behavior in Schizoaffective Disorder
This medication has helped me deal with the voices. I would recommend it to those individuals seeking relief from auditory hallucinations.
5Patient Review
4/23/2012
Clozaril for Schizophrenia
At first, the weekly blood work was tough to handle. Now I only have to go monthly. This medication has been a true wonder drug for me and I haven't had to stay in the hospital for over two years now.
4.7Patient Review
4/10/2011
Clozaril for Suicidal Behavior in Schizoaffective Disorder
So far, clozaril has been working great for me. I've only been taking it for a week, but I feel like I'm able to cope better already. I've tried other drugs in the past, but this one seems to be the best fit for me.
4.3Patient Review
9/3/2009
Clozaril for Schizophrenia
Clozaril was a godsend for my son. He was very ill and we had tried every treatment available with little success. After starting Clozaril, he is now doing great in college with only a fraction of his previous symptoms.
3.7Patient Review
10/19/2010
Clozaril for Schizophrenia
Clozaril has made a world of difference for my son. He was taking a lot of other drugs that didn't really help, and some even made things worse. But this medication has helped him to act more like himself again.
3.7Patient Review
6/16/2015
Clozaril for Schizophrenia
I've been using this medication for over two decades, but recently stopped and then restarted. I'm not seeing the same results as before and am now experiencing depression where I didn't before.
3.7Patient Review
1/13/2009
Clozaril for Schizophrenia
My son has been on this medication for a week to help with his bi-polar disorder and psycho-affective disorder. So far, he is still very sleepy and delusional.
3.3Patient Review
3/20/2009
Clozaril for Treatment-Resistant Schizophrenia
I've been using this medication for a while now and it's starting to impact my memory. It's becoming difficult to keep a job or maintain relationships when I can't remember things. That said, it's still been helpful overall.
3.3Patient Review
4/23/2013
Clozaril for Schizophrenia
I've been on clozapine since 1995 and it's been effective for me. The weight gain is an issue, but I'm able to keep a full-time job because of the medication. I have been told that there may be a slight heart issue that is not caused by clozapine, but I would try everything else before starting this medication again.
1Patient Review
9/7/2013
Clozaril for Schizophrenia
After my diagnosis last year, I was hospitalized for four months. I was put on Cloazaril after trying three other atypical antipsychotics, and it has been a total game-changer. Within three months, I was back to work and happy again. The downside is that it can make you sleepy, and you have to get your blood drawn and weigh yourself every week.
1Patient Review
5/4/2010
Clozaril for Treatment-Resistant Schizophrenia
I was on Clozaril for a number of years, but then I started having major issues with things like memory and weight gain. Thankfully, my doctor was able to switch me to a different medication.
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Patient Q&A Section about clozaril

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the main side effects of Clozaril?

"Side effects that are commonly seen include feeling sleepy, dizzy, having a headache, trembling, a fast heart rate, low blood pressure, passing out, drooling, sweating, a dry mouth, visual issues, constipation, feeling nauseous, and having a fever."

Answered by AI

What type of drug is Clozaril?

"Clozapine is a medication that belongs to a class of antipsychotics called atypical antipsychotics. This medication works by changing the activity of natural substances in the brain."

Answered by AI

What is the drug Clozaril used for?

"Clozapine is a medication that works in the brain to treat schizophrenia by rebalancing dopamine and serotonin. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic."

Answered by AI

What is the most serious side effect of clozapine?

"The following text contains information about the possible side effects of Clozapine. Clozapine may cause drowsiness, blurred vision, convulsions (seizures), or difficulties with thinking or controlling body movements, which may lead to falls, fractures or other injuries."

Answered by AI

Clinical Trials for Clozaril

Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.
Waitlist Available
Has No Placebo
The University of Iowa
Image of Mayo Clinic in Rochester, United States.

Weight Loss Medications for Obesity in Bipolar Disorder

18 - 65
All Sexes
Rochester, MN
The goal of this clinical trial is to identify the specific characteristics (phenotypes) that may be useful to help select the right medication for weight loss, and to study the effect of individualized guided medication in patients with bipolar disorder ages 18-65. The main questions it aims to answer are: * Can the investigators compare the distribution of obesity characteristics (hungry brain, hungry gut, emotional hunger) between bipolar patients and non-bipolar participants (comparing from IRB #24-002375)? * Can the investigators evaluate the feasibility of anti-obesity medication (AOM) in patients with bipolar disorder? Participation will last for about 17-18 weeks and includes 7 in-person study visits, 4 phone call visits, and 12 virtual group therapy sessions. The first visit lasts about 2 hours and includes going over the informed consent form, a diagnostic interview to confirm diagnosis, gathering vital signs, mood questionnaires, an ECG, and urine drug and pregnancy tests (if applicable). The second visit lasts about 6-7 hours and involves multiple procedures and completing questionnaires to determine which study drug would allow participants to lose weight most effectively. At the third visit, participants will be assigned to take one of three FDA approved medications for weight loss: Semaglutide (Wegovy®), Naltrexone/Bupropion (Contrave®), or Phentermine/Topiramate (Qysmia®). It is possible that participants could be assigned to a group that receives no study medication. All participants will be enrolled in a 12-week virtual group therapy program targeted for weight loss. On this third visit the investigators will also gather vital signs, and participants will give a sample of blood. After the third visit, participants will come in for study visits every 4 weeks for 16 weeks (4 visits) to assess medication adherence, vitals, and answer questions about mood and eating (participants will also give a sample of blood at the 8-week and 16-week visits). Every two weeks in between in-person visits, the study team will call participants to assess medication adherence. Participants will be compensated for time spent in this study.
Phase 4
Waitlist Available
Mayo ClinicMark A Frye, M.D.
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Emraclidine for Schizophrenia

18 - 65
All Sexes
Little Rock, AR
Schizophrenia is a common and severe psychiatric illness characterized by extreme disturbances of cognition and thought, affecting language, perception and sense of self. This study will assess adverse events, change in disease activity, and how oral emraclidine moves through the body in adult participants with schizophrenia Emraclidine is an investigational drug being developed for the treatment of schizophrenia. Participants are placed in one of two parts, Part A or Part B, where each group will receive a different treatment. Participants will receive either oral emraclidine or placebo. Approximately 258 participants will be enrolled across roughly 32 sites in the United States. Participants in Part A will be assigned to one of multiple ascending doses of emraclidine or placebo administered orally for 14 days or up to 21 days. Participants in Part B will receive Emraclidine or placebo administered orally for up to 42 days. Participants will be followed for 30 days after the last dose of the study drug. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Woodland International Research Group /ID# 275747 (+4 Sites)ABBVIE INC.AbbVie
Have you considered Clozaril clinical trials? We made a collection of clinical trials featuring Clozaril, we think they might fit your search criteria.Go to Trials
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iTEST for Psychosis

18 - 65
All Sexes
San Diego, CA
The purpose of this study is to evaluate the effectiveness of a psychosocial intervention called iTEST for people with psychotic disorders that targets introspective accuracy, or the ability to accurately gauge ones abilities. iTEST combines daily cognitive training on a mobile device with coaching that addresses recovery goals. In this trial, we will randomize people to one of two interventions conditions, iTEST or a control condition that receives coaching and cognitive training that does not emphasize introspective accuracy. Both interventions will take place over 12 weeks and participants will be asked to complete assessments at baseline, 6 weeks, 12 weeks, and 24 weeks. The primary outcome of the study is community functioning. Participants will be from three metropolitan areas: San Diego, Dallas, or Miami.
Recruiting
Has No Placebo
UC San Diego (+2 Sites)Amy Pinkham, PhD
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