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What is Iluvien
Fluocinolone acetonideThe Generic name of this drug
Treatment SummaryFluocinolone acetonide is a corticosteroid used in skin medications and implantable devices. It was first developed by Taro Pharmaceuticals and approved by the FDA in 2016. The drug has a high lipophilicity and has been studied extensively for its potential use in corticosteroid devices.
Neo-Synalaris the brand name
Iluvien Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Neo-Synalar
Fluocinolone acetonide
1963
93
Approved as Treatment by the FDA
Fluocinolone acetonide, otherwise called Neo-Synalar, is approved by the FDA for 3 uses like Chronic Uveitis and Uveitis .Chronic Uveitis
Uveitis
Uveitis
Effectiveness
How Iluvien Affects PatientsFluocinolone acetonide is a medication used to reduce inflammation. When used in the eyes, it is inserted as a tiny implant and has been found to reduce the recurrence of uveitis (inflammation of the eye) by two-fold compared to not taking any medication. However, it can cause an increase in the pressure inside the eye, so this should be monitored.
How Iluvien works in the bodyFluocinolone acetonide is a corticosteroid that helps reduce inflammation by binding to the glucocorticoid receptor and entering the cell nucleus. In the nucleus, it binds to genes that create a protein called lipocortin. This protein stops the production of other proteins that create inflammation, like prostaglandins, leukotrienes, and arachidonic acid. This allows fluocinolone to reduce inflammation in the body.
When to interrupt dosage
The measure of Iluvien is conditional upon the diagnosed condition, including Hemorrhoids, Perianal erythema and Itch. The measure of the dosage shifts, in line with the technique of delivery (e.g. Kit or Emulsion - Topical) featured in the table below.Condition
Dosage
Administration
Itching
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Perianal erythema
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Scab
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Postoperative Care
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Skin Diseases
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Dermatitis, Seborrheic
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Eczema
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Uveitis
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Otitis Externa
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Uveitis
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Psoriasis of the scalp
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Wound Infection
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Pressure Ulcer
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Diabetic Macular Edema
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Otitis Media
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Skin
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Blister
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Skin Inflammation caused by Bacterial Infections
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Conjunctivitis, Bacterial
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Chronic disease
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Warnings
Iluvien has four contraindications and should not be taken when afflicted by any of the conditions listed in the following table.Iluvien ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Fluocinolone Acetonide may interact with conjunctiva
Mycoses
Do Not Combine
External auditory canal structure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fluocinolone Acetonide may interact with conjunctiva
Common Iluvien Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Abatacept.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Fluocinolone acetonide.
Abetimus
Major
The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Abetimus.
Iluvien Toxicity & Overdose RiskStudies have not yet been conducted to determine the effects of fluocinolone acetonide on fertility or cancer risk. However, while some corticosteroids have been found to be genotoxic, fluocinolone acetonide was determined to be non-genotoxic in an Ames test and a mouse lymphoma TK assay.
Iluvien Novel Uses: Which Conditions Have a Clinical Trial Featuring Iluvien?
97 active studies are presently investigating the potential of Iluvien to ameliorate Atopic Dermatitis, Otitis Media and Otitis Externa.Condition
Clinical Trials
Trial Phases
Hemorrhoids
2 Actively Recruiting
Phase 4, Not Applicable
Perianal erythema
0 Actively Recruiting
Eczema
60 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
Blister
0 Actively Recruiting
Otitis Externa
0 Actively Recruiting
Psoriasis of the scalp
1 Actively Recruiting
Phase 4
Otitis
3 Actively Recruiting
Not Applicable
Hemorrhoids
0 Actively Recruiting
Scab
0 Actively Recruiting
Ear structure
0 Actively Recruiting
Skin
0 Actively Recruiting
Skin Diseases
0 Actively Recruiting
Fissure in Ano
1 Actively Recruiting
Phase 1
Postoperative Care
2 Actively Recruiting
Not Applicable, Early Phase 1
Wound Infection
0 Actively Recruiting
Skin Inflammation caused by Bacterial Infections
0 Actively Recruiting
Uveitis
4 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 3
Conjunctivitis, Bacterial
0 Actively Recruiting
Coinfection
0 Actively Recruiting
Chronic disease
0 Actively Recruiting
Patient Q&A Section about iluvien
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How much does ILUVIEN cost?
"The Iluvien intravitreal implant 0.19 mg costs approximately $9,276 for a single implant, depending on which pharmacy you visit."
Answered by AI
Is ILUVIEN an implant?
"ILUVIEN® is a 0.19 mg implant that is injected into the eye to treat diabetic macular edema in patients who have been treated with corticosteroids in the past and did not experience a significant increase in eye pressure."
Answered by AI
Who manufactures ILUVIEN?
"Some key points about Alimera: They gained distribution in the United States, they educated physicians on the benefits of Soothe, Alaway was approved by the FDA, and they sold both products to Bausch and Lomb."
Answered by AI
What is ILUVIEN used for?
"The implant is designed to help people with DME who have already tried other types of corticosteroids and have not had a significant increase in eye pressure."
Answered by AI