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What is Paroxetine Mesylate
ParoxetineThe Generic name of this drug
Treatment SummaryParoxetine, also known as Paxil, is a medication used to treat anxiety disorders, depression, post-traumatic stress disorder and menopause symptoms. It was approved by the FDA in the early 1990s and is more potent and selective than other serotonin reuptake inhibitors. Paroxetine may cause withdrawal symptoms when stopped, and has a similar side effect profile to other SSRIs. The controlled release formulation helps decrease nausea which can sometimes be associated with paroxetine.
Paxilis the brand name
Paroxetine Mesylate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Paxil
Paroxetine
1993
429
Approved as Treatment by the FDA
Paroxetine, also known as Paxil, is approved by the FDA for 3 uses which include Vasomotor Symptoms Associated With Menopause and Hot flashes .Vasomotor Symptoms Associated With Menopause
Helps manage Vasomotor Symptoms Associated With Menopause
Hot flashes
Helps manage Menopause
Hot Flashes
Helps manage Vasomotor Symptoms Associated With Menopause
Effectiveness
How Paroxetine Mesylate Affects PatientsParoxetine is a medication used to treat depression, anxiety disorders, posttraumatic stress disorder, obsessive-compulsive disorder, and menopause-related symptoms. It works by blocking the reuptake of serotonin. It usually takes about 6 weeks for Paroxetine to start working. When taken with certain other drugs (monoamine oxidase inhibitors), it can cause a dangerous reaction called serotonin syndrome, so it is important to wait at least two weeks after stopping the other drug before taking Paroxetine.
How Paroxetine Mesylate works in the bodyParoxetine works by blocking the reuptake of serotonin, a chemical in the brain. This increases the amount of serotonin in the body, which helps to relieve symptoms. Paroxetine is more potent than other drugs in its class, like citalopram, fluoxetine, and fluvoxamine. The exact way it helps relieve symptoms of menopause is not known, but it may work by affecting temperature regulation. Paroxetine also binds to other receptors, including adrenergic alpha-1 and alpha-2 receptors and serotonin 5-HT1A, 5-HT2A, and 5
When to interrupt dosage
The quantity of Paroxetine Mesylate is dependent upon the diagnosed condition, including Post Traumatic Stress Disorder, Depression and Irritable Bowel Syndrome (IBS). The amount of dosage also is contingent upon the mode of delivery (e.g. Oral or Capsule - Oral) detailed in the table underneath.Condition
Dosage
Administration
Generalized Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Irritable Bowel Syndrome
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Depression
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot Flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Premature Ejaculation
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Panic Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Social Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Obsessive-Compulsive Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Post Traumatic Stress Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Warnings
Paroxetine Mesylate has five contraindications and is not to be taken if any of the conditions in the following table are present.Paroxetine Mesylate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Serotonin Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Paroxetine may interact with Pulse Frequency
Common Paroxetine Mesylate Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Paroxetine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Paroxetine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Paroxetine.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Paroxetine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Paroxetine is combined with Aclidinium.
Paroxetine Mesylate Toxicity & Overdose RiskThe toxic dose of paroxetine in mice and rats has been found to be 350 mg/kg. The lowest reported fatal overdose of paroxetine is 400 mg, while the highest reported survived overdose is 2000 mg. Symptoms of paroxetine overdose can include fatigue, fever, high blood pressure, rapid heartbeat, nausea, vomiting, drowsiness, trembling, dizziness, agitation, confusion, anxiety, headache, sweating, dilated pupils, seizures, tingling sensations, serotonin syndrome, and changes in mental status. There is no antidote to an overdose of paroxetine.
Paroxetine Mesylate Novel Uses: Which Conditions Have a Clinical Trial Featuring Paroxetine Mesylate?
539 active studies are currently assessing the potential of Paroxetine Mesylate to alleviate Post Traumatic Stress Disorder, Premature Ejaculation and Menopausal symptoms.Condition
Clinical Trials
Trial Phases
Depression
186 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Social Anxiety Disorder
20 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Generalized Anxiety Disorder
4 Actively Recruiting
Not Applicable, Phase 2, Phase 1
Obsessive-Compulsive Disorder
18 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1
Post Traumatic Stress Disorder
281 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3
Panic Disorder
12 Actively Recruiting
Not Applicable, Phase 2
Irritable Bowel Syndrome
8 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Hot Flashes
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting
Hot flashes
12 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4
Paroxetine Mesylate Reviews: What are patients saying about Paroxetine Mesylate?
4.3Patient Review
8/18/2014 This medication unfortunately just makes me tired.
4Patient Review
10/7/2016 This medication helped me to effectively manage my panic attacks and social anxiety. I still experience these symptoms, but they are much less severe than before. It took about a week for the effects of this drug to be noticeable.
3.3Patient Review
2/5/20083.3Patient Review
4/27/20093Patient Review
3/15/2010 This medication helps me with my anxiety, for the most part. I still have occasional episodes where I get anxious, but it's manageable. As for sexual side effects, they happen often enough that it's become a bit of a nuisance.
2.7Patient Review
2/25/2011 I wasn't really blown away by this treatment. It was just okay in my opinion.
1Patient Review
5/18/2015 I've been on this medication for two decades now. I saw an immediate change that has kept me satisfied for all these years. However, I have put on weight and lost interest in sex; because of these side effects, I'm thinking about changing to a different antidepressant.
Patient Q&A Section about paroxetine mesylate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is paroxetine mesylate used for?
"Paroxetine is most commonly used to treat depression, panic attacks, OCD, and anxiety disorders by helping to restore the balance of serotonin in the brain. Paroxetine is classified as a selective serotonin reuptake inhibitor (SSRI), which is a type of drug that works by preventing serotonin from being reabsorbed by the brain."
Answered by AI
What is paroxetine mesylate 7.5 mg cap?
"There is now a nonhormonal option for the treatment of moderate to severe VMS associated with menopause that has been approved by the US Food and Drug Administration. Brisdelle (paroxetine 7.5 mg) is the first medication of its kind to receive this approval."
Answered by AI
Is paroxetine used for menopause?
"Paroxetine 7.5 mg is the only nonhormonal treatment that has been approved in the United States for moderate to severe vasomotor symptoms associated with menopause."
Answered by AI
Is paroxetine and paroxetine mesylate the same?
"The active ingredient in the generic and brand-name version of the drug paroxetine is the same, and the two versions of the drug have similar pharmacokinetic and pharmacodynamic properties."
Answered by AI