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What is Procardia Xl
NifedipineThe Generic name of this drug
Treatment SummaryNifedipine, also known as BAY a 1040, is a medication used to treat high blood pressure. It works by changing the way calcium moves into cells of the heart and blood vessels, which helps relax the blood vessels and reduce the pressure of the blood. It was developed by Bayer in 1972 and approved by the FDA in 1981. It is part of a family of medications called dihydropyridine L-type calcium channel blockers and is one of the first such drugs approved for use. Since then, newer medications with slower onsets and longer durations of action, such as amlodipine, have
Procardiais the brand name
Procardia Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Procardia
Nifedipine
1981
355
Approved as Treatment by the FDA
Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Angina, Stable and Failed conventional therapy .Angina, Stable
Helps manage Chronic Stable Angina Pectoris
Failed conventional therapy
Helps manage Failed conventional therapy
Vasospastic Angina
Helps manage Vasospastic Angina
Effectiveness
How Procardia Xl Affects PatientsNifedipine helps to reduce blood pressure and increase oxygen to the heart. It typically needs to be taken three times a day, with the amount taken depending on the individual's needs. People taking this drug should be aware of the risks of low blood pressure, chest pain, and heart attack.
How Procardia Xl works in the bodyNifedipine is a drug that helps reduce blood pressure and ease chest pain. It works by blocking calcium channels in the walls of blood vessels, which prevents calcium from entering the cells. This reduces resistance in the arteries, increasing blood flow and oxygen to the heart.
When to interrupt dosage
The amount of Procardia Xl is contingent upon the established condition, such as Achalasia, Ureteral Calculus and Hypertensive disease. The dosage depends on the approach of delivery (e.g. Tablet, film coated, extended release or Capsule) as delineated in the table below.Condition
Dosage
Administration
Failed conventional therapy
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Pulmonary Edema
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Proctalgia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Altitude Sickness
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Hypertensive disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Vasospastic Angina
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Raynaud Disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Ureteral Calculi
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Angina, Stable
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Hypertensive Emergency
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Fissure;Anal
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Anal sphincter hypertonia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Premature Labour
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Esophageal Achalasia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Pulmonary Hypertension
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Warnings
Procardia Xl has one identified contraindication, so it should not be employed for the circumstances noted in the following table.Procardia Xl ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Nifedipine may interact with Pulse Frequency
Common Procardia Xl Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Nifedipine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Nifedipine.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.
Procardia Xl Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 1022mg/kg and 202mg/kg in mice. Overdosing on this drug can lead to low blood pressure, abnormal heart rate, and abnormal communication between the upper and lower parts of the heart. Treatment may involve monitoring vital signs, elevating extremities, and administering medications to raise the blood pressure and increase calcium levels.
Procardia Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Procardia Xl?
101 active studies are underway to investigate the potential of Procardia Xl in providing relief for Achalasia, Hypertensive Emergency and Anal Fissure.Condition
Clinical Trials
Trial Phases
Esophageal Achalasia
0 Actively Recruiting
Pulmonary Edema
0 Actively Recruiting
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypertensive disease
21 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Premature Labour
4 Actively Recruiting
Not Applicable, Phase 2
Altitude Sickness
0 Actively Recruiting
Raynaud Disease
0 Actively Recruiting
Pulmonary Hypertension
25 Actively Recruiting
Phase 4, Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1
Proctalgia
0 Actively Recruiting
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Fissure;Anal
0 Actively Recruiting
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Anal sphincter hypertonia
0 Actively Recruiting
Ureteral Calculi
0 Actively Recruiting
Failed conventional therapy
0 Actively Recruiting
Procardia Xl Reviews: What are patients saying about Procardia Xl?
5Patient Review
10/6/2016 I started this medication when I was pregnant with my first child at 32 years old. I had been diagnosed with preeclampsia and toxemia, which resulted in high blood pressure that needed to be controlled with medication. This drug has worked well for me and I have not experienced any side effects.
5Patient Review
6/18/2012 I appreciate that this medication doesn't make me drowsy.
4.7Patient Review
1/18/20124Patient Review
3/26/2014 I've been taking Procardia XL for five years to manage hypertension, and it's been effective. However, the side effects have gradually gotten worse and now include joint pain, gas, indigestion, hair loss, decreased libido, and more. The most recent change has been my doctor lowering my dose--here's hoping that helps!
4Patient Review
11/23/2013 I've been on Procardia for nine months now. I generally feel tired, and my legs often ache. Additionally, I experience swelling in my hands and feet when standing for long periods of time. headaches are also common. However, I haven't had to use nitroglycerin once since starting this medication regimen.
3.7Patient Review
3/18/2013 I experienced some pretty bad joint pain after starting this medication. It began about two weeks in and I also felt dizzy and had low blood pressure.
3.7Patient Review
2/12/2012 I've been on this medication for a little over a week now. So far, I'm experiencing mood swings, slow heart rate, and shortness of breath.
3.7Patient Review
11/18/2015 I started noticing my gums were growing over my teeth, so I went to the dentist. Turns out, one of the side effects of the Procardia I'd been taking was gum growth. I've also experienced frequent urination as a result of this medication.
3.7Patient Review
1/29/20123.7Patient Review
5/2/2013 I've been taking this for a little over three months now and I started to notice that about 10-12 hours after taking it, I would feel dizzy. My doctor diagnosed me with vertigo but I'm not convinced it's entirely unrelated to the Procardia XL. Has anyone else experienced this side effect?
3Patient Review
9/22/2016 I saw some improvement when I increased my dosage, but the swelling in my ankles has become really bad. I'm going to try discontinuing the medication and see if that helps.
2.7Patient Review
6/8/2015 Since starting this medication, I have been very tired in the mornings. In addition, I've experienced increased muscle and joint pain, as well as constipation. The side effects of this drug are terrible; 60mgs once a day has been my dosage. I'm going to lower the mgs and see if that helps. If not, we'll try another medication.
2.7Patient Review
2/25/2020 I took this medication at night because I had heard it would make me sleepy. Unfortunately, I found that it made me exhausted during the day and also gave me headaches that no amount of painkillers could touch.
2.7Patient Review
11/12/20112.3Patient Review
7/14/2021 Procardia was given to me to help with preeclampsia a few weeks after giving birth. It did lower my blood pressure, but the migraines and flush feelings were really unpleasant. I stopped taking it after a few months and switched to diet and exercise, which worked out better for me in the long run.
Patient Q&A Section about procardia xl
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is nifedipine no longer used?
"Initially, nifedipine was one of the most popular medications to treat hypertension. However, concerns about its safety and tolerability, as well as the introduction of new types of antihypertensive medications, led to its decline in use. Additionally, data showing that other types of medications are more effective in reducing mortality rates has also contributed to nifedipine's decline in popularity."
Answered by AI
Does Procardia XL cause weight gain?
"This medicine may cause fluid retention in some patients, which can lead to symptoms such as bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or loss. If you experience any of these symptoms, be sure to tell your doctor right away."
Answered by AI
What are side effects of Procardia XL?
"The following text lists some potential side effects of a medication. If you experience any of these side effects, tell your doctor or pharmacist."
Answered by AI