Tradjenta

Physical Activity, Type 2 Diabetes, Diet
Treatment
4 FDA approvals
20 Active Studies for Tradjenta

What is Tradjenta

LinagliptinThe Generic name of this drug
Treatment SummaryLinagliptin is a medication used to treat type II diabetes. It works differently than other similar medications by having a non-linear effect on the body and not being eliminated by the kidneys. It was approved by the FDA in 2011 and is sold under the brand name Tradjenta.
Tradjentais the brand name
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Tradjenta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tradjenta
Linagliptin
2011
17

Approved as Treatment by the FDA

Linagliptin, also known as Tradjenta, is approved by the FDA for 4 uses like Type 2 Diabetes Mellitus and Diet .
Type 2 Diabetes Mellitus
Used to treat Type 2 Diabetes Mellitus in combination with Empagliflozin
Diet
Used to treat Diet in combination with Empagliflozin
Physical Activity
Used to treat Exercise in combination with Empagliflozin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Empagliflozin

Effectiveness

How Tradjenta Affects PatientsTaking 5mg of linagliptin helps to reduce blood sugar levels by blocking an enzyme (DPP-4) in the body for 24 hours or more. This blocking of the enzyme increases the amount of a hormone (GLP-1) that helps to lower levels of sugar in the blood and reduce sugar in the blood when fasting.
How Tradjenta works in the bodyLinagliptin is a drug that prevents an enzyme called DPP-4 from breaking down certain proteins in the body. These proteins, GLP-1 and GIP, work to stimulate the release of insulin from the pancreas. This increases the amount of insulin released in response to glucose, and decreases the breakdown of glycogen in the liver.

When to interrupt dosage

The prescribed dose of Tradjenta hinges upon the indicated condition, such as Physical Activity, Diet and Type 2 Diabetes. The measure of dosage is based on the administration approach (e.g. Tablet - Oral or Tablet) specified in the table hereunder.
Condition
Dosage
Administration
Physical Activity
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Type 2 Diabetes
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Diet
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral

Warnings

Tradjenta has six contraindications, and it should not be taken while enduring any of the conditions specified in the table below.Tradjenta Contraindications
Condition
Risk Level
Notes
Acute Coryza
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Metabolic acidosis
Do Not Combine
Dialysis therapy
Do Not Combine
Kidney Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Linagliptin may interact with Pulse Frequency
There are 20 known major drug interactions with Tradjenta.
Common Tradjenta Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Linagliptin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Linagliptin.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Linagliptin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Linagliptin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Linagliptin.
Tradjenta Toxicity & Overdose RiskLinagliptin is suitable for use in people of all ages, genders, weights, and races, as well as those with kidney or liver problems. Clinical trials have shown that people aged 10-18 can take linagliptin without any major side effects. Animal studies have suggested a higher risk of lymphoma in female rats who are given doses over 200 times the recommended amount for humans. Linagliptin has also been found to be non-mutagenic, non-clastogenic, and not to affect fertility.
image of a doctor in a lab doing drug, clinical research

Tradjenta Novel Uses: Which Conditions Have a Clinical Trial Featuring Tradjenta?

196 active trials are being conducted to assess the potential of Tradjenta in promoting Physical Activity, managing Type 2 Diabetes and Diet modification.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
170 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diet
6 Actively Recruiting
Not Applicable, Phase 1
Physical Activity
33 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1

Tradjenta Reviews: What are patients saying about Tradjenta?

5Patient Review
7/14/2018
Tradjenta for Type 2 Diabetes Mellitus
After a two week trial, my blood sugar readings were very good. I was able to switch from taking insulin before each meal to just once a day. Trajenta and one shot of long lasting insulin per day has been working great for me.
5Patient Review
2/12/2020
Tradjenta for Type 2 Diabetes Mellitus
I've been taking this drug for about a year with great results. My A1C dropped two points and I couldn't be happier. Now my insurance doesn't want to cover it, so I'm trying something new which makes me very nervous.
5Patient Review
1/5/2019
Tradjenta for Type 2 Diabetes Mellitus
This treatment is effective and has no negative side effects that I've experienced.
3.7Patient Review
7/3/2016
Tradjenta for Type 2 Diabetes Mellitus
I noticed that my sugar levels have been elevated since taking this medication. I also experienced increased mucus production, which I never would have attributed to the tradjenta if it weren't for reading other reviews. It's quite expensive, though.
3.3Patient Review
4/28/2019
Tradjenta for Type 2 Diabetes Mellitus
I often wake up with pain in my mid-back, but it goes away once I get out of bed. Has anyone else experienced something similar?
View All Reviews
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Patient Q&A Section about tradjenta

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Tradjenta the same as metformin?

"Tradjenta may help to lower blood sugar levels, but may cause bodily aches. Glucophage is a medication that is typically used to help control blood sugar levels and lower the risk of death from diabetes, but a few people may not be able to tolerate the stomach side effects."

Answered by AI

What is the drug Tradjenta used for?

"If you have type 2 diabetes, your body does not make or use insulin well. Insulin is a hormone that helps glucose get into your cells to give them energy. Tradjenta (linagliptin) is an oral diabetes medicine that helps control blood sugar levels by stimulating the release of insulin after a meal. Tradjenta is for people with type 2 diabetes. It is sometimes used in combination with other diabetes medications.

If you have type 2 diabetes, your body doesn't process insulin as effectively as it should. Insulin is a hormone that helps glucose get into your cells to give them energy. Tradjenta (linagliptin) is an oral diabetes medication that helps control blood sugar levels by stimulating the release of insulin after a meal. Tradjenta is for people with type 2 diabetes and is sometimes used in combination with other diabetes medications."

Answered by AI

Is Tradjenta and Januvia the same thing?

"Tradjenta works by regulating the levels of insulin your body produces after eating.

Are Januvia and Tradjenta the same medication?

Januvia (sitagliptin) and Tradjenta (linagliptin) are oral diabetes medicines for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Tradjenta works by regulating the levels of insulin your body produces after eating."

Answered by AI

What is the side effect of Tradjenta?

"Potential side effects of this medication may include a runny or stuffy nose, a sore throat, a cough, or diarrhea."

Answered by AI

Clinical Trials for Tradjenta

Have you considered Tradjenta clinical trials? We made a collection of clinical trials featuring Tradjenta, we think they might fit your search criteria.
Have you considered Tradjenta clinical trials? We made a collection of clinical trials featuring Tradjenta, we think they might fit your search criteria.
Have you considered Tradjenta clinical trials? We made a collection of clinical trials featuring Tradjenta, we think they might fit your search criteria.
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