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Mitochondrial Transplant for Stroke

Seattle, WA
N/A
Recruiting
Led By Melanie S Walker, MD
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Eligible for angioplasty (microcatheter-based balloon/mechanical and chemical angioplasty) to treat acute cerebral vasospasm after aneurysmal subarachnoid hemorrhage
Eligible for endovascular thrombectomy to treat acute large vessel occlusion
Must not have
Hemodynamically unstable patients in whom standard of care endovascular reperfusion treatment cannot safely be performed or completed
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to six hours after procedure completion
Awards & highlights
No Placebo-Only Group

Summary

This trial will infuse healthy mitochondria into the brains of patients who are experiencing ischemia in order to improve their condition.

See full description
Who is the study for?
This trial is for patients eligible for endovascular thrombectomy due to acute large vessel occlusion or angioplasty after subarachnoid hemorrhage. Candidates must be stable enough for standard reperfusion treatment and able to give consent. Those with mitochondrial diseases, unable to undergo MRI, or hemodynamically unstable cannot participate.Check my eligibility
What is being tested?
The study tests the infusion of a patient's own healthy mitochondria into brain vessels affected by ischemia during standard endovascular reperfusion therapy. The goal is to see if this can help recover brain tissue that isn't getting enough blood flow due to stroke.See study design
What are the potential side effects?
Potential side effects are not explicitly listed but may include reactions related to the mitochondrial transplantation procedure itself or complications from the endovascular therapies used in treating cerebral ischemia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am a candidate for a special procedure to treat brain vessel narrowing after a specific type of stroke.
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I am a candidate for a procedure to remove a large blood clot in my vessel.
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Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I cannot undergo standard stroke treatments due to my unstable condition.
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Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 3 hours post-mitochondrial infusion
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 3 hours post-mitochondrial infusion for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Incidence of severe adverse events during mitochondrial infusion
Incidence of severe adverse events related to muscle biopsy
Incidence of severe adverse vascular events immediately post-mitochondrial infusion
+1 more
Secondary study objectives
Reduction of infarct volume post-mitochondrial infusion

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: TransplantationExperimental Treatment1 Intervention
Endovascular infusion

Find a Location

Closest Location:Harborview Medical Center· Seattle, WA

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,853 Previous Clinical Trials
2,022,091 Total Patients Enrolled
Melanie S Walker, MDPrincipal InvestigatorUniversity of Washington

Media Library

Autologous Mitochondrial Transplant Clinical Trial Eligibility Overview. Trial Name: NCT04998357 — N/A
Cerebral Ischemia Research Study Groups: Transplantation
Cerebral Ischemia Clinical Trial 2023: Autologous Mitochondrial Transplant Highlights & Side Effects. Trial Name: NCT04998357 — N/A
Autologous Mitochondrial Transplant 2023 Treatment Timeline for Medical Study. Trial Name: NCT04998357 — N/A
~4 spots leftby Apr 2026
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