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HMPL-760 for Non-Hodgkin's Lymphoma

Phase 1
Waitlist Available
Research Sponsored by Hutchison Medipharma Limited
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from 1st dose of study drug to the time of progressive disease, assessed up to 36 months
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing HMPL-760, a new drug, in patients with certain blood cancers who have already tried other treatments. The drug works by blocking a protein that helps cancer cells grow, aiming to slow down or stop their growth.

Eligible Conditions
  • Non-Hodgkin's Lymphoma
  • Waldenstrom Macroglobulinemia
  • Medial Collateral Ligament
  • Follicular Lymphoma
  • Chronic Lymphocytic Leukemia
  • Marginal Zone Lymphoma
  • Richter Syndrome
  • Lymphoplasmacytic Lymphoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from 1st dose of study drug to the time of progressive disease, assessed up to 36 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and from 1st dose of study drug to the time of progressive disease, assessed up to 36 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Incidence of AEs/SAEs
Incidence of DLTs
MTD
+1 more
Secondary study objectives
Chemokines
Clinical Benefit Rate (CBR)
Duration of Response (DoR)
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment1 Intervention
All patients to receive HMPL-760 daily.

Find a Location

Who is running the clinical trial?

Hutchison Medipharma LimitedLead Sponsor
101 Previous Clinical Trials
13,572 Total Patients Enrolled
HutchmedLead Sponsor
36 Previous Clinical Trials
6,479 Total Patients Enrolled
Vijay Jayaprakash, MBBS, PHDStudy DirectorHutchison Medipharma Limited
1 Previous Clinical Trials
75 Total Patients Enrolled
~0 spots leftby Dec 2025
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