Your session is about to expire
← Back to Search
mRNA Therapy
mRNA-3927 for Propionic Acidemia
Phase 1 & 2
Recruiting
Research Sponsored by ModernaTX, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Must not have
History of liver and/or kidney transplant.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group
Summary
This trial will test the long-term safety of a medication for propionic acidemia, a rare metabolic disorder.
Who is the study for?
This trial is for individuals with propionic acidemia who were previously in the mRNA-3927-P101 study. They must have completed that study's end-of-treatment visit within 10 days of starting this one. People can't join if they've had a liver or kidney transplant, aren't expected to benefit from more treatment, or have health issues that make it risky.
What is being tested?
The trial is testing the long-term safety and effectiveness of a drug called mRNA-3927 in patients with propionic acidemia who took part in an earlier phase of research. It continues where the previous study left off.
What are the potential side effects?
Since this is an extension study for mRNA-3927, side effects are monitored over a longer period but may include reactions related to immune response, potential organ stress, and other unforeseen issues as observed during ongoing surveillance.
Eligibility Criteria
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have had a liver or kidney transplant.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: mRNA-3927Experimental Treatment1 Intervention
Participants will receive the applicable dose identified during Study mRNA-3927-P101 (NCT04159103) on Day 1. The dose can be adjusted based on Sponsor recommendation.
Find a Location
Who is running the clinical trial?
ModernaTX, Inc.Lead Sponsor
121 Previous Clinical Trials
66,785,038 Total Patients Enrolled
3 Trials studying Propionic Acidemia
365 Patients Enrolled for Propionic Acidemia
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have had a liver or kidney transplant.
Research Study Groups:
This trial has the following groups:- Group 1: mRNA-3927
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.