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Anti-fibrinolytic agent

Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris

Phase 2 & 3
Waitlist Available
Led By Steven Daveluy
Research Sponsored by Wayne State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks

Summary

This trial is testing a skin cream called topical tranexamic acid to see if it can lighten dark spots from acne. It is aimed at people who can't use the usual treatment because of side effects. The cream works by reducing skin pigment and has few reported side effects.

Eligible Conditions
  • Postinflammatory Hyperpigmentation

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Bile Pigments
Change from Baseline Pigmentation at 4 Weeks.
Change from Baseline Pigmentation at 8 Weeks.

Side effects data

From 2015 Phase 4 trial • 29 Patients • NCT02063035
8%
Postoperative wound infection
8%
Postoperative wound infection after release from hospital
8%
Myocardial infaction
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Tranexamic Acid

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Right Side of FaceExperimental Treatment1 Intervention
Patients will apply topical tranexamic acid to the dark spots on the one side of their face.
Group II: Left Side of FacePlacebo Group1 Intervention
Patients will apply the vehicle cream without any medication to the dark spots on one side of their face.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tranexamic Acid
2011
Completed Phase 4
~2740

Find a Location

Who is running the clinical trial?

Wayne State UniversityLead Sponsor
314 Previous Clinical Trials
110,897 Total Patients Enrolled
Steven DaveluyPrincipal InvestigatorWSUPG Dermatology
~0 spots leftby Dec 2025
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